TENM4

Entrez Summary: The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016].
UniProt Summary: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small- diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cardiac cell fate specification
central nervous system myelin formation
positive regulation of gastrulation
cardiac cell fate commitment
cardiac muscle cell proliferation
striated muscle cell proliferation
positive regulation of myelination
muscle cell proliferation
myelin assembly
central nervous system myelination
axon ensheathment in central nervous system
positive regulation of oligodendrocyte differentiation
cardiac muscle tissue growth
gastrulation with mouth forming second
heart growth
positive regulation of embryonic development
regulation of gastrulation
regulation of oligodendrocyte differentiation
regulation of myelination
oligodendrocyte development
positive regulation of glial cell differentiation
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion molecule binding
positive regulation of nervous system process
oligodendrocyte differentiation
regulation of glial cell differentiation
positive regulation of gliogenesis
cell fate specification
organ growth
cellular component assembly involved in morphogenesis
myelination
glial cell development
axon ensheathment
ensheathment of neurons
regulation of gliogenesis
cardiocyte differentiation
regulation of embryonic development
regulation of nervous system process
gastrulation
cardiac muscle tissue development