TESK2

Entrez Summary: N/A
UniProt Summary: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

focal adhesion assembly
cell-substrate adherens junction assembly
protein serine/threonine/tyrosine kinase activity
adherens junction assembly
cell-substrate junction assembly
adherens junction organization
protein tyrosine kinase activity
cell-matrix adhesion
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
cell junction assembly
cell-substrate adhesion
cell junction organization
protein kinase activity
nuclear body
protein serine/threonine kinase activity
actin cytoskeleton organization
spermatogenesis
male gamete generation
actin filament-based process
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
cell adhesion
biological adhesion
protein phosphorylation
multi-organism reproductive process
cytoskeleton organization
phosphorylation
reproductive process
reproduction
ATP binding