TESPA1

Gene Information

Official Symbol: TESPA1
Official Name: thymocyte expressed, positive selection associated 1
Aliases and Previous Symbols: N/A
Entrez ID: 9840
UniProt: A2RU30
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13061
Expression level (log2 read counts): 3.71

Expression Distribution

Screen	Score
Lenalidomide 20μM R07 exp375	1.79
JQ1 0.8μM R08 exp435	1.82
Deferoxamine 11μM R07 exp350	2.14

COP9 signalosome assembly
positive regulation of T cell differentiation in thymus
positive regulation of T cell receptor signaling pathway
positive regulation of antigen receptor-mediated signaling pathway
regulation of T cell differentiation in thymus
COP9 signalosome
regulation of T cell receptor signaling pathway
regulation of antigen receptor-mediated signaling pathway
positive regulation of T cell differentiation
positive regulation of lymphocyte differentiation
regulation of T cell differentiation
positive regulation of leukocyte differentiation
regulation of lymphocyte differentiation
positive regulation of hemopoiesis
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
positive regulation of cell-cell adhesion
regulation of leukocyte differentiation
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
regulation of hemopoiesis
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cell adhesion
cellular protein-containing complex assembly
positive regulation of immune response
endoplasmic reticulum membrane
positive regulation of cell differentiation
regulation of immune response
positive regulation of immune system process
positive regulation of developmental process
protein-containing complex assembly
regulation of immune system process