TFAP2D

Entrez Summary: N/A
UniProt Summary: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inferior colliculus development
corpora quadrigemina development
midbrain development
negative regulation of neuron apoptotic process
transcription factor complex
negative regulation of neuron death
regulation of neuron apoptotic process
regulation of neuron death
RNA polymerase II regulatory region sequence-specific DNA binding
brain development
head development
negative regulation of apoptotic process
negative regulation of programmed cell death
central nervous system development
negative regulation of cell death
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
regulation of apoptotic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process