TFB2M [The Human Chemical-Genetic Interaction Map Project]

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======= TFB2M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFB2M
  * **<color #00a2e8>Official Name</color>**: transcription factor B2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64216|64216]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H5Q4|Q9H5Q4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFB2M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFB2M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RrnaAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription initiation from mitochondrial promoter|
|rRNA (adenine-N6,N6-)-dimethyltransferase activity|
|mitochondrial transcription|
|rRNA methylation|
|rRNA modification|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|transcription coregulator activity|
|RNA methylation|
|mitochondrial gene expression|
|RNA modification|
|rRNA processing|
|DNA-templated transcription, initiation|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|mitochondrion organization|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.82|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.05|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl3|MRPL3]]|0.496|
|[[:human genes:m:mrpl28|MRPL28]]|0.487|
|[[:human genes:m:mrpl33|MRPL33]]|0.466|
|[[:human genes:a:aars2|AARS2]]|0.465|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.46|
|[[:human genes:n:nars2|NARS2]]|0.46|
|[[:human genes:v:vars2|VARS2]]|0.459|
|[[:human genes:m:mrps18a|MRPS18A]]|0.456|
|[[:human genes:d:dap3|DAP3]]|0.454|
|[[:human genes:q:qrsl1|QRSL1]]|0.446|
|[[:human genes:p:pars2|PARS2]]|0.443|
|[[:human genes:p:pet112|PET112]]|0.442|
|[[:human genes:m:mrps22|MRPS22]]|0.441|
|[[:human genes:m:mrpl21|MRPL21]]|0.432|
|[[:human genes:t:trub2|TRUB2]]|0.428|
|[[:human genes:m:mrps21|MRPS21]]|0.427|
|[[:human genes:r:rpusd3|RPUSD3]]|0.426|
|[[:human genes:m:mars2|MARS2]]|0.423|
|[[:human genes:h:hars2|HARS2]]|0.423|
|[[:human genes:m:mrps34|MRPS34]]|0.422|
|[[:human genes:m:mrps7|MRPS7]]|0.422|
|[[:human genes:m:mrps9|MRPS9]]|0.419|
|[[:human genes:m:mrps12|MRPS12]]|0.418|
|[[:human genes:p:ptcd3|PTCD3]]|0.417|
|[[:human genes:m:mrpl45|MRPL45]]|0.417|
|[[:human genes:l:lars2|LARS2]]|0.415|
|[[:human genes:m:mrps6|MRPS6]]|0.413|
|[[:human genes:p:polrmt|POLRMT]]|0.413|
|[[:human genes:t:tars2|TARS2]]|0.412|
|[[:human genes:m:mrp63|MRP63]]|0.41|
|[[:human genes:m:mrpl17|MRPL17]]|0.41|
|[[:human genes:w:wbscr16|WBSCR16]]|0.409|
|[[:human genes:t:tomm20|TOMM20]]|0.407|
|[[:human genes:m:mrpl23|MRPL23]]|0.406|
|[[:human genes:s:selrc1|SELRC1]]|0.404|
|[[:human genes:e:eral1|ERAL1]]|0.404|
|[[:human genes:e:ears2|EARS2]]|0.403|
|[[:human genes:m:mrps16|MRPS16]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 63/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|2/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFB2M Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>