TFB2M

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 63/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	2/26
breast	4/33
central nervous system	2/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	3/20
lung	8/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	5/29
uterus	0/5

Expression Distribution

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.72
Oligomycin-A 2μM R00 exp25	1.82
CoCl2 18μM R07 exp346	2.05
Thimerosal 0.85μM R08 exp529	2.1

transcription initiation from mitochondrial promoter
rRNA (adenine-N6,N6-)-dimethyltransferase activity
mitochondrial transcription
rRNA methylation
rRNA modification
mitochondrial RNA metabolic process
mitochondrial nucleoid
transcription coregulator activity
RNA methylation
mitochondrial gene expression
RNA modification
rRNA processing
DNA-templated transcription, initiation
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
mitochondrial matrix
ncRNA processing
mitochondrion organization
ribonucleoprotein complex biogenesis
ncRNA metabolic process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
RNA binding
positive regulation of transcription, DNA-templated
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process