TFDP2 [The Human Chemical-Genetic Interaction Map Project]

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======= TFDP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFDP2
  * **<color #00a2e8>Official Name</color>**: transcription factor Dp-2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7029|7029]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14188|Q14188]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFDP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFDP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E2F TDP|
|DP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|positive regulation of establishment of protein localization to mitochondrion|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|RNA polymerase II transcription factor complex|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|regulation of membrane permeability|
|transcription coregulator activity|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|positive regulation of mitochondrion organization|
|G1/S transition of mitotic cell cycle|
|signal transduction by p53 class mediator|
|cell cycle G1/S phase transition|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|mitochondrial transport|
|negative regulation of cell cycle phase transition|
|protein domain specific binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|transcription factor binding|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of cell cycle phase transition|
|positive regulation of establishment of protein localization|
|heart development|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|membrane organization|
|circulatory system development|
|regulation of cellular localization|
|positive regulation of transport|
|cell cycle process|
|regulation of protein localization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.88|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.77|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.7|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.81|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.88|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.94|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.94|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.99|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.3|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.3|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfdp1|TFDP1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFDP2 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>