TFDP2

Gene Information

Official Symbol: TFDP2
Official Name: transcription factor Dp-2
Aliases and Previous Symbols: N/A
Entrez ID: 7029
UniProt: Q14188
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Isonicotinamide 500μM R03 exp129	-1.88
Deferoxamine 11μM R07 exp350	-1.77
Tunicamycin 0.04μM R07 exp418	1.7
Dynasore 7μM R08 exp436	1.81
Pterostilbene 16μM R02 exp78	1.88
MLN-4924 0.2μM R00 exp21	1.94
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.94
BI-D1870 3.15μM R02 exp66	1.97
TRAIL 5ng/ml R00 exp35	1.99
Bleomycin 5μM R08 exp459	2.3
Bortezomib 0.005μM R00 exp6	2.3
Olaparib 4μM R08 exp512	2.42

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17848
Expression level (log2 read counts): 7.54

Expression Distribution

E2F TDP
DP

regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of transcription involved in G1/S transition of mitotic cell cycle
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA damage checkpoint
positive regulation of establishment of protein localization to mitochondrion
mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
RNA polymerase II transcription factor complex
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
signal transduction involved in cell cycle checkpoint
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
regulation of membrane permeability
transcription coregulator activity
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
mitotic DNA integrity checkpoint
signal transduction in response to DNA damage
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
positive regulation of mitochondrion organization
G1/S transition of mitotic cell cycle
signal transduction by p53 class mediator
cell cycle G1/S phase transition
positive regulation of protein localization to membrane
mitochondrial membrane organization
DNA damage checkpoint