TFF2

Entrez Summary: N/A
UniProt Summary: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CXCR4 chemokine receptor binding
negative regulation of gastric acid secretion
regulation of gastric acid secretion
negative regulation of digestive system process
maintenance of gastrointestinal epithelium
epithelial structure maintenance
regulation of digestive system process
digestive system process
chemokine-mediated signaling pathway
response to chemokine
cellular response to chemokine
digestion
tissue homeostasis
negative regulation of secretion
multicellular organismal homeostasis
anatomical structure homeostasis
negative regulation of transport
regulation of system process
cytokine-mediated signaling pathway
regulation of secretion
cellular response to cytokine stimulus
response to cytokine
negative regulation of multicellular organismal process
extracellular space
homeostatic process
regulation of transport
system process