TFIP11 [The Human Chemical-Genetic Interaction Map Project]

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======= TFIP11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFIP11
  * **<color #00a2e8>Official Name</color>**: tuftelin interacting protein 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=24144|24144]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBB9|Q9UBB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFIP11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFIP11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIP N|
|G-patch|
|GCFC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of DNA ligation|
|negative regulation of DNA ligase activity|
|spliceosomal complex disassembly|
|negative regulation of ligase activity|
|regulation of DNA ligase activity|
|U2-type post-mRNA release spliceosomal complex|
|regulation of DNA ligation|
|negative regulation of double-strand break repair via nonhomologous end joining|
|protection from non-homologous end joining at telomere|
|regulation of ligase activity|
|telomere maintenance in response to DNA damage|
|ribonucleoprotein complex disassembly|
|telomere capping|
|regulation of double-strand break repair via nonhomologous end joining|
|negative regulation of double-strand break repair|
|negative regulation of DNA repair|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|biomineral tissue development|
|biomineralization|
|telomere maintenance|
|telomere organization|
|negative regulation of protein binding|
|nuclear chromosome, telomeric region|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|negative regulation of protein complex assembly|
|negative regulation of binding|
|nucleic acid binding|
|regulation of response to DNA damage stimulus|
|regulation of protein binding|
|extracellular matrix|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|regulation of binding|
|RNA splicing|
|cellular component disassembly|
|nuclear speck|
|regulation of protein complex assembly|
|mRNA processing|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|chromosome organization|
|negative regulation of molecular function|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|homeostatic process|
|RNA metabolic process|
|cellular response to stress|
|tissue development|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.15|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.79|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.71|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.72|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.73|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.75|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.76|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.77|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.78|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.79|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.8|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.83|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.84|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.87|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.93|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.94|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.95|
|[[:results:exp453|B02 10μM R08 exp453]]|2|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.06|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.07|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.08|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.12|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.13|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.15|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.59|
|[[:results:exp210|LB-100 2μM R05 exp210]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.626|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.619|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.598|
|[[:human genes:c:cbwd5|CBWD5]]|0.578|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.578|
|[[:human genes:c:cdc6|CDC6]]|0.576|
|[[:human genes:c:chd4|CHD4]]|0.575|
|[[:human genes:c:c14orf93|C14orf93]]|0.571|
|[[:human genes:t:ticrr|TICRR]]|0.569|
|[[:human genes:c:cbwd3|CBWD3]]|0.563|
|[[:human genes:o:orc6|ORC6]]|0.563|
|[[:human genes:v:vasn|VASN]]|0.561|
|[[:human genes:r:rps12|RPS12]]|0.56|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.558|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.558|
|[[:human genes:g:gar1|GAR1]]|0.557|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.557|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.557|
|[[:human genes:s:syt9|SYT9]]|0.555|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.551|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.549|
|[[:human genes:c:cbwd6|CBWD6]]|0.549|
|[[:human genes:a:akirin2|AKIRIN2]]|0.548|
|[[:human genes:o:orc1|ORC1]]|0.545|
|[[:human genes:m:mt1e|MT1E]]|0.544|
|[[:human genes:s:slc4a1|SLC4A1]]|0.541|
|[[:human genes:i:ik|IK]]|0.541|
|[[:human genes:s:sf3a2|SF3A2]]|0.536|
|[[:human genes:p:ppfia4|PPFIA4]]|0.536|
|[[:human genes:p:psmd3|PSMD3]]|0.533|
|[[:human genes:s:supt5h|SUPT5H]]|0.53|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.53|
|[[:human genes:n:nsf|NSF]]|0.529|
|[[:human genes:c:copg1|COPG1]]|0.528|
|[[:human genes:g:gid4|GID4]]|0.522|
|[[:human genes:r:rps5|RPS5]]|0.521|
|[[:human genes:n:nupl1|NUPL1]]|0.52|
|[[:human genes:s:snrnp70|SNRNP70]]|0.52|
|[[:human genes:t:tceb3c|TCEB3C]]|0.52|
|[[:human genes:r:rbm39|RBM39]]|0.519|
|[[:human genes:p:psmb4|PSMB4]]|0.518|
|[[:human genes:r:rfxank|RFXANK]]|0.518|
|[[:human genes:u:ubap1|UBAP1]]|0.517|
|[[:human genes:p:plk4|PLK4]]|0.517|
|[[:human genes:c:cdc45|CDC45]]|0.516|
|[[:human genes:c:cep192|CEP192]]|0.516|
|[[:human genes:d:ddtl|DDTL]]|0.516|
|[[:human genes:r:riok2|RIOK2]]|0.515|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.513|
|[[:human genes:c:cdc73|CDC73]]|0.512|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.512|
|[[:human genes:k:kctd17|KCTD17]]|0.512|
|[[:human genes:e:eif3g|EIF3G]]|0.511|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.511|
|[[:human genes:c:ccna2|CCNA2]]|0.511|
|[[:human genes:t:tspy8|TSPY8]]|0.511|
|[[:human genes:c:cope|COPE]]|0.511|
|[[:human genes:s:stil|STIL]]|0.509|
|[[:human genes:r:rps2|RPS2]]|0.509|
|[[:human genes:a:acsf2|ACSF2]]|0.509|
|[[:human genes:a:aqr|AQR]]|0.508|
|[[:human genes:c:cdca3|CDCA3]]|0.507|
|[[:human genes:n:narfl|NARFL]]|0.507|
|[[:human genes:c:ckap5|CKAP5]]|0.502|
|[[:human genes:c:copa|COPA]]|0.501|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.5|
|[[:human genes:n:nup43|NUP43]]|0.498|
|[[:human genes:w:wdr87|WDR87]]|0.497|
|[[:human genes:p:psma6|PSMA6]]|0.496|
|[[:human genes:e:egr2|EGR2]]|0.496|
|[[:human genes:s:snrpa1|SNRPA1]]|0.496|
|[[:human genes:m:myo1h|MYO1H]]|0.496|
|[[:human genes:c:copb1|COPB1]]|0.495|
|[[:human genes:d:dtl|DTL]]|0.494|
|[[:human genes:v:vps54|VPS54]]|0.493|
|[[:human genes:c:chaf1a|CHAF1A]]|0.492|
|[[:human genes:c:cactin|CACTIN]]|0.491|
|[[:human genes:a:ankle1|ANKLE1]]|0.491|
|[[:human genes:s:s1pr4|S1PR4]]|0.49|
|[[:human genes:l:lrr1|LRR1]]|0.49|
|[[:human genes:m:myh2|MYH2]]|0.489|
|[[:human genes:m:madcam1|MADCAM1]]|0.487|
|[[:human genes:r:rpl14|RPL14]]|0.486|
|[[:human genes:p:psmd7|PSMD7]]|0.485|
|[[:human genes:n:nbpf10|NBPF10]]|0.484|
|[[:human genes:t:twistnb|TWISTNB]]|0.483|
|[[:human genes:i:iscu|ISCU]]|0.481|
|[[:human genes:p:pcf11|PCF11]]|0.481|
|[[:human genes:f:fbxw9|FBXW9]]|0.481|
|[[:human genes:r:rps3a|RPS3A]]|0.481|
|[[:human genes:r:rrn3|RRN3]]|0.48|
|[[:human genes:p:psmc1|PSMC1]]|0.479|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.478|
|[[:human genes:s:sap30bp|SAP30BP]]|0.478|
|[[:human genes:p:psmc6|PSMC6]]|0.478|
|[[:human genes:s:sult2b1|SULT2B1]]|0.478|
|[[:human genes:r:rrp15|RRP15]]|0.477|
|[[:human genes:n:npipb5|NPIPB5]]|0.475|
|[[:human genes:g:golga6a|GOLGA6A]]|0.474|
|[[:human genes:e:exd1|EXD1]]|0.474|
|[[:human genes:r:rps9|RPS9]]|0.474|
|[[:human genes:o:or10g3|OR10G3]]|0.473|
|[[:human genes:d:disp2|DISP2]]|0.473|
|[[:human genes:c:cmya5|CMYA5]]|0.472|
|[[:human genes:t:tyms|TYMS]]|0.472|
|[[:human genes:c:chmp2a|CHMP2A]]|0.472|
|[[:human genes:a:aatf|AATF]]|0.472|
|[[:human genes:r:rbbp5|RBBP5]]|0.47|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.47|
|[[:human genes:s:ssh2|SSH2]]|0.469|
|[[:human genes:r:rps28|RPS28]]|0.469|
|[[:human genes:s:sf3a1|SF3A1]]|0.469|
|[[:human genes:r:rpl34|RPL34]]|0.467|
|[[:human genes:g:gon4l|GON4L]]|0.466|
|[[:human genes:n:nufip2|NUFIP2]]|0.466|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.466|
|[[:human genes:r:rpl35|RPL35]]|0.463|
|[[:human genes:h:hivep3|HIVEP3]]|0.463|
|[[:human genes:p:polr2j3|POLR2J3]]|0.463|
|[[:human genes:o:ogfr|OGFR]]|0.462|
|[[:human genes:s:samd1|SAMD1]]|0.461|
|[[:human genes:n:napa|NAPA]]|0.46|
|[[:human genes:a:arcn1|ARCN1]]|0.459|
|[[:human genes:p:psmd11|PSMD11]]|0.458|
|[[:human genes:p:prpf19|PRPF19]]|0.458|
|[[:human genes:d:ddx47|DDX47]]|0.457|
|[[:human genes:r:rpl37a|RPL37A]]|0.456|
|[[:human genes:d:dock6|DOCK6]]|0.456|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.455|
|[[:human genes:p:plekha4|PLEKHA4]]|0.454|
|[[:human genes:o:osbp|OSBP]]|0.454|
|[[:human genes:n:nfatc4|NFATC4]]|0.453|
|[[:human genes:c:cwc22|CWC22]]|0.453|
|[[:human genes:p:psmc5|PSMC5]]|0.453|
|[[:human genes:n:ndc1|NDC1]]|0.453|
|[[:human genes:u:utp3|UTP3]]|0.453|
|[[:human genes:m:med14|MED14]]|0.452|
|[[:human genes:f:fam160a1|FAM160A1]]|0.452|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.449|
|[[:human genes:l:loc643669|LOC643669]]|0.449|
|[[:human genes:c:ccdc94|CCDC94]]|0.448|
|[[:human genes:b:bysl|BYSL]]|0.447|
|[[:human genes:c:copz1|COPZ1]]|0.446|
|[[:human genes:s:supt6h|SUPT6H]]|0.446|
|[[:human genes:p:pole|POLE]]|0.445|
|[[:human genes:e:eif4a3|EIF4A3]]|0.445|
|[[:human genes:k:kif3c|KIF3C]]|0.444|
|[[:human genes:r:rad51|RAD51]]|0.444|
|[[:human genes:z:znf106|ZNF106]]|0.444|
|[[:human genes:c:cacna1a|CACNA1A]]|0.444|
|[[:human genes:a:aprt|APRT]]|0.444|
|[[:human genes:x:xab2|XAB2]]|0.444|
|[[:human genes:n:nol12|NOL12]]|0.444|
|[[:human genes:h:hap1|HAP1]]|0.443|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.443|
|[[:human genes:t:tagln|TAGLN]]|0.443|
|[[:human genes:n:nipbl|NIPBL]]|0.443|
|[[:human genes:a:abt1|ABT1]]|0.441|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.441|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.441|
|[[:human genes:z:znf148|ZNF148]]|0.441|
|[[:human genes:g:golga6b|GOLGA6B]]|0.44|
|[[:human genes:w:wdr90|WDR90]]|0.44|
|[[:human genes:t:top1mt|TOP1MT]]|0.44|
|[[:human genes:n:nup160|NUP160]]|0.44|
|[[:human genes:g:golga8h|GOLGA8H]]|0.44|
|[[:human genes:g:gprin2|GPRIN2]]|0.44|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.439|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.439|
|[[:human genes:r:rfpl3|RFPL3]]|0.438|
|[[:human genes:f:fam20a|FAM20A]]|0.438|
|[[:human genes:m:mepce|MEPCE]]|0.438|
|[[:human genes:f:fam25b|FAM25B]]|0.437|
|[[:human genes:s:snip1|SNIP1]]|0.437|
|[[:human genes:e:eif3cl|EIF3CL]]|0.437|
|[[:human genes:h:htatsf1|HTATSF1]]|0.436|
|[[:human genes:e:exosc5|EXOSC5]]|0.436|
|[[:human genes:u:utp20|UTP20]]|0.436|
|[[:human genes:n:nup85|NUP85]]|0.435|
|[[:human genes:n:nol10|NOL10]]|0.435|
|[[:human genes:t:thoc1|THOC1]]|0.435|
|[[:human genes:s:sec13|SEC13]]|0.435|
|[[:human genes:z:znf830|ZNF830]]|0.434|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.433|
|[[:human genes:a:anks1a|ANKS1A]]|0.432|
|[[:human genes:a:ahctf1|AHCTF1]]|0.432|
|[[:human genes:p:paf1|PAF1]]|0.432|
|[[:human genes:t:trappc11|TRAPPC11]]|0.431|
|[[:human genes:c:cwc15|CWC15]]|0.431|
|[[:human genes:a:add2|ADD2]]|0.43|
|[[:human genes:r:rpl9|RPL9]]|0.43|
|[[:human genes:r:rps14|RPS14]]|0.43|
|[[:human genes:r:rpsa|RPSA]]|0.429|
|[[:human genes:x:xylt2|XYLT2]]|0.429|
|[[:human genes:m:mat2a|MAT2A]]|0.428|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.428|
|[[:human genes:n:nup155|NUP155]]|0.428|
|[[:human genes:s:shpk|SHPK]]|0.427|
|[[:human genes:i:itga2b|ITGA2B]]|0.427|
|[[:human genes:t:tgm5|TGM5]]|0.427|
|[[:human genes:s:sf3a3|SF3A3]]|0.426|
|[[:human genes:t:tonsl|TONSL]]|0.426|
|[[:human genes:p:pola2|POLA2]]|0.426|
|[[:human genes:e:exosc9|EXOSC9]]|0.426|
|[[:human genes:a:atxn1|ATXN1]]|0.425|
|[[:human genes:p:ppie|PPIE]]|0.425|
|[[:human genes:a:ankle2|ANKLE2]]|0.424|
|[[:human genes:r:rilpl2|RILPL2]]|0.424|
|[[:human genes:p:polr2f|POLR2F]]|0.424|
|[[:human genes:c:cln6|CLN6]]|0.424|
|[[:human genes:g:gosr2|GOSR2]]|0.424|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.424|
|[[:human genes:a:aamp|AAMP]]|0.422|
|[[:human genes:m:myb|MYB]]|0.422|
|[[:human genes:u:upf1|UPF1]]|0.422|
|[[:human genes:p:psmb3|PSMB3]]|0.422|
|[[:human genes:e:eif3a|EIF3A]]|0.422|
|[[:human genes:e:exosc3|EXOSC3]]|0.422|
|[[:human genes:p:psmb2|PSMB2]]|0.421|
|[[:human genes:t:timeless|TIMELESS]]|0.42|
|[[:human genes:n:nol8|NOL8]]|0.42|
|[[:human genes:c:cgb2|CGB2]]|0.42|
|[[:human genes:c:cnpy3|CNPY3]]|0.42|
|[[:human genes:s:sel1l|SEL1L]]|0.419|
|[[:human genes:m:myo18a|MYO18A]]|0.419|
|[[:human genes:t:tspy1|TSPY1]]|0.418|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.418|
|[[:human genes:w:wdr75|WDR75]]|0.418|
|[[:human genes:m:mdm2|MDM2]]|0.417|
|[[:human genes:p:polr1a|POLR1A]]|0.416|
|[[:human genes:k:krt78|KRT78]]|0.416|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:c:cox8a|COX8A]]|0.415|
|[[:human genes:n:nop56|NOP56]]|0.415|
|[[:human genes:e:exosc4|EXOSC4]]|0.414|
|[[:human genes:t:trappc8|TRAPPC8]]|0.414|
|[[:human genes:z:znf574|ZNF574]]|0.414|
|[[:human genes:g:golga8o|GOLGA8O]]|0.414|
|[[:human genes:g:golga8j|GOLGA8J]]|0.413|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.413|
|[[:human genes:s:sf3b5|SF3B5]]|0.413|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.413|
|[[:human genes:p:psap|PSAP]]|0.413|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.412|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.412|
|[[:human genes:u:uqcrh|UQCRH]]|0.412|
|[[:human genes:i:igfn1|IGFN1]]|0.412|
|[[:human genes:t:topbp1|TOPBP1]]|0.411|
|[[:human genes:r:rrp7a|RRP7A]]|0.41|
|[[:human genes:p:pola1|POLA1]]|0.41|
|[[:human genes:d:dhx38|DHX38]]|0.41|
|[[:human genes:c:ctr9|CTR9]]|0.41|
|[[:human genes:p:polr2l|POLR2L]]|0.409|
|[[:human genes:v:vps28|VPS28]]|0.408|
|[[:human genes:n:nxf1|NXF1]]|0.408|
|[[:human genes:p:pwp2|PWP2]]|0.407|
|[[:human genes:c:cdt1|CDT1]]|0.407|
|[[:human genes:z:znf655|ZNF655]]|0.407|
|[[:human genes:m:mms22l|MMS22L]]|0.407|
|[[:human genes:s:specc1l|SPECC1L]]|0.406|
|[[:human genes:n:nup153|NUP153]]|0.405|
|[[:human genes:p:plrg1|PLRG1]]|0.405|
|[[:human genes:m:med29|MED29]]|0.405|
|[[:human genes:t:tuba8|TUBA8]]|0.405|
|[[:human genes:n:nuf2|NUF2]]|0.404|
|[[:human genes:r:rpl10a|RPL10A]]|0.404|
|[[:human genes:p:polr2d|POLR2D]]|0.404|
|[[:human genes:i:incenp|INCENP]]|0.404|
|[[:human genes:i:ints6|INTS6]]|0.403|
|[[:human genes:c:col15a1|COL15A1]]|0.403|
|[[:human genes:p:prim1|PRIM1]]|0.403|
|[[:human genes:z:zfand5|ZFAND5]]|0.402|
|[[:human genes:c:casc5|CASC5]]|0.402|
|[[:human genes:n:nup54|NUP54]]|0.402|
|[[:human genes:n:nup205|NUP205]]|0.402|
|[[:human genes:t:trim52|TRIM52]]|0.401|
|[[:human genes:i:ints5|INTS5]]|0.401|
|[[:human genes:p:pole2|POLE2]]|0.4|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.4|
|[[:human genes:p:prmt8|PRMT8]]|0.4|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.4|
|[[:human genes:c:ccdc116|CCDC116]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 176/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|9/28|
|bone|9/26|
|breast|11/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|3/21|
|liver|1/20|
|lung|22/75|
|lymphocyte|4/16|
|ovary|10/26|
|pancreas|6/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFIP11 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>