TFIP11

Gene Information

Official Symbol: TFIP11
Official Name: tuftelin interacting protein 11
Aliases and Previous Symbols: N/A
Entrez ID: 24144
UniProt: Q9UBB9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269|PubMed:19103666}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-2.15
SB743921 0.001μM R05 exp244	-1.79
QNZ 0.01μM R05 exp241	1.71
Wortmannin 5μM R00 exp38	1.71
CCCP 1μM R00 exp11	1.72
MSC2530818 10μM R07 exp379	1.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.73
Vincristine 0.0005μM R04 exp190	1.73
Rifampicin 1μM R00 exp31	1.75
Apcin 25μM plus proTAME 2μM R04 exp177	1.76
BN82002 4μM R07 exp340	1.77
Q15 1 to 2μM on day4 R04 exp164	1.78
RO-3306 3 to 4μM on day4 R04 exp165	1.79
Bortezomib 0.005μM R00 exp6	1.8
BI-D1870 2μM R04 exp162	1.83
ABT-702 5μM R07 exp318	1.84
Latrunculin-B 10μM R07 exp374	1.84
DABN 2μM R00 exp16	1.87
THZ531 0.11μM R07 exp409	1.93
UM0011500 5μM R05 exp245	1.94
LB-100 4.1μM R02 exp72	1.95
B02 10μM R08 exp453	2
L-BMAA 500 to 750μM on day4 R04 exp185	2
3-Bromopyruvate 7μM R04 exp175	2.06
TRAIL 5ng/ml R00 exp35	2.07
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.08
Ethanol 0.01 R05 exp234	2.12
5-Fluorouracil 2μM R00 exp1	2.13
Hypoxia 5%O2 R04 exp191	2.15
Doxycycline 10μM R00 exp18	2.59
LB-100 2μM R05 exp210	3.1

Gene	Correlation
TBC1D3G	0.626
TBC1D3H	0.619
TBC1D3F	0.598
CBWD5	0.578
TBC1D3C	0.578
CDC6	0.576
CHD4	0.575
C14orf93	0.571
TICRR	0.569
CBWD3	0.563
ORC6	0.563
VASN	0.561
RPS12	0.56
TBC1D3I	0.558
TBC1D3E	0.558
GAR1	0.557
TBC1D3L	0.557
TBC1D3K	0.557
SYT9	0.555
TBC1D3	0.551
TCEB3CL2	0.549
CBWD6	0.549
AKIRIN2	0.548
ORC1	0.545
MT1E	0.544
SLC4A1	0.541
IK	0.541
SF3A2	0.536
PPFIA4	0.536
PSMD3	0.533
SUPT5H	0.53
C1QTNF9B	0.53
NSF	0.529
COPG1	0.528
GID4	0.522
RPS5	0.521
NUPL1	0.52
SNRNP70	0.52
TCEB3C	0.52
RBM39	0.519
PSMB4	0.518
RFXANK	0.518
UBAP1	0.517
PLK4	0.517
CDC45	0.516
CEP192	0.516
DDTL	0.516
RIOK2	0.515
RPS19BP1	0.513
CDC73	0.512
ATP6V1C1	0.512
KCTD17	0.512
EIF3G	0.511
TCEB3CL	0.511
CCNA2	0.511
TSPY8	0.511
COPE	0.511
STIL	0.509
RPS2	0.509
ACSF2	0.509
AQR	0.508
CDCA3	0.507
NARFL	0.507
CKAP5	0.502
COPA	0.501
C2orf27B	0.5
NUP43	0.498
WDR87	0.497
PSMA6	0.496
EGR2	0.496
SNRPA1	0.496
MYO1H	0.496
COPB1	0.495
DTL	0.494
VPS54	0.493
CHAF1A	0.492
CACTIN	0.491
ANKLE1	0.491
S1PR4	0.49
LRR1	0.49
MYH2	0.489
MADCAM1	0.487
RPL14	0.486
PSMD7	0.485
NBPF10	0.484
TWISTNB	0.483
ISCU	0.481
PCF11	0.481
FBXW9	0.481
RPS3A	0.481
RRN3	0.48
PSMC1	0.479
HIST2H2BF	0.478
SAP30BP	0.478
PSMC6	0.478
SULT2B1	0.478
RRP15	0.477
NPIPB5	0.475
GOLGA6A	0.474
EXD1	0.474
RPS9	0.474
OR10G3	0.473
DISP2	0.473
CMYA5	0.472
TYMS	0.472
CHMP2A	0.472
AATF	0.472
RBBP5	0.47
DNTTIP2	0.47
SSH2	0.469
RPS28	0.469
SF3A1	0.469
RPL34	0.467
GON4L	0.466
NUFIP2	0.466
FOXD4L2	0.466
RPL35	0.463
HIVEP3	0.463
POLR2J3	0.463
OGFR	0.462
SAMD1	0.461
NAPA	0.46
ARCN1	0.459
PSMD11	0.458
PRPF19	0.458
DDX47	0.457
RPL37A	0.456
DOCK6	0.456
CCDC64B	0.455
PLEKHA4	0.454
OSBP	0.454
NFATC4	0.453
CWC22	0.453
PSMC5	0.453
NDC1	0.453
UTP3	0.453
MED14	0.452
FAM160A1	0.452
PLA2G4F	0.449
LOC643669	0.449
CCDC94	0.448
BYSL	0.447
COPZ1	0.446
SUPT6H	0.446
POLE	0.445
EIF4A3	0.445
KIF3C	0.444
RAD51	0.444
ZNF106	0.444
CACNA1A	0.444
APRT	0.444
XAB2	0.444
NOL12	0.444
HAP1	0.443
TP53TG3B	0.443
TAGLN	0.443
NIPBL	0.443
ABT1	0.441
TP53TG3C	0.441
TP53TG3	0.441
ZNF148	0.441
GOLGA6B	0.44
WDR90	0.44
TOP1MT	0.44
NUP160	0.44
GOLGA8H	0.44
GPRIN2	0.44
PDE4DIP	0.439
HIST1H2BE	0.439
RFPL3	0.438
FAM20A	0.438
MEPCE	0.438
FAM25B	0.437
SNIP1	0.437
EIF3CL	0.437
HTATSF1	0.436
EXOSC5	0.436
UTP20	0.436
NUP85	0.435
NOL10	0.435
THOC1	0.435
SEC13	0.435
ZNF830	0.434
HNRNPC	0.433
ANKS1A	0.432
AHCTF1	0.432
PAF1	0.432
TRAPPC11	0.431
CWC15	0.431
ADD2	0.43
RPL9	0.43
RPS14	0.43
RPSA	0.429
XYLT2	0.429
MAT2A	0.428
GOLGA6L3	0.428
NUP155	0.428
SHPK	0.427
ITGA2B	0.427
TGM5	0.427
SF3A3	0.426
TONSL	0.426
POLA2	0.426
EXOSC9	0.426
ATXN1	0.425
PPIE	0.425
ANKLE2	0.424
RILPL2	0.424
POLR2F	0.424
CLN6	0.424
GOSR2	0.424
ARHGEF35	0.424
AAMP	0.422
MYB	0.422
UPF1	0.422
PSMB3	0.422
EIF3A	0.422
EXOSC3	0.422
PSMB2	0.421
TIMELESS	0.42
NOL8	0.42
CGB2	0.42
CNPY3	0.42
SEL1L	0.419
MYO18A	0.419
TSPY1	0.418
ATP6AP1	0.418
WDR75	0.418
MDM2	0.417
POLR1A	0.416
KRT78	0.416
PSMC2	0.415
COX8A	0.415
NOP56	0.415
EXOSC4	0.414
TRAPPC8	0.414
ZNF574	0.414
GOLGA8O	0.414
GOLGA8J	0.413
GOLGA6L4	0.413
SF3B5	0.413
ATP6V1A	0.413
PSAP	0.413
HIST2H3C	0.412
HIST2H3A	0.412
UQCRH	0.412
IGFN1	0.412
TOPBP1	0.411
RRP7A	0.41
POLA1	0.41
DHX38	0.41
CTR9	0.41
POLR2L	0.409
VPS28	0.408
NXF1	0.408
PWP2	0.407
CDT1	0.407
ZNF655	0.407
MMS22L	0.407
SPECC1L	0.406
NUP153	0.405
PLRG1	0.405
MED29	0.405
TUBA8	0.405
NUF2	0.404
RPL10A	0.404
POLR2D	0.404
INCENP	0.404
INTS6	0.403
COL15A1	0.403
PRIM1	0.403
ZFAND5	0.402
CASC5	0.402
NUP54	0.402
NUP205	0.402
TRIM52	0.401
INTS5	0.401
POLE2	0.4
NCKAP1L	0.4
PRMT8	0.4
SKIV2L2	0.4
CCDC116	0.4

Global Fraction of Cell Lines Where Essential: 176/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	8/28
blood	9/28
bone	9/26
breast	11/33
central nervous system	10/56
cervix	0/4
colorectal	6/17
esophagus	1/13
fibroblast	1/1
gastric	3/16
kidney	3/21
liver	1/20
lung	22/75
lymphocyte	4/16
ovary	10/26
pancreas	6/24
peripheral nervous system	0/16
plasma cell	4/15
prostate	1/1
skin	5/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 1077
Expression level (log2 read counts): 6.67

Expression Distribution

TIP N
G-patch
GCFC

negative regulation of DNA ligation
negative regulation of DNA ligase activity
spliceosomal complex disassembly
negative regulation of ligase activity
regulation of DNA ligase activity
U2-type post-mRNA release spliceosomal complex
regulation of DNA ligation
negative regulation of double-strand break repair via nonhomologous end joining
protection from non-homologous end joining at telomere
regulation of ligase activity
telomere maintenance in response to DNA damage
ribonucleoprotein complex disassembly
telomere capping
regulation of double-strand break repair via nonhomologous end joining
negative regulation of double-strand break repair
negative regulation of DNA repair
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
catalytic step 2 spliceosome
spliceosomal complex
biomineral tissue development
biomineralization
telomere maintenance
telomere organization
negative regulation of protein binding
nuclear chromosome, telomeric region
negative regulation of DNA metabolic process
regulation of DNA repair
negative regulation of protein complex assembly
negative regulation of binding
nucleic acid binding
regulation of response to DNA damage stimulus
regulation of protein binding
extracellular matrix
protein-containing complex disassembly
ribonucleoprotein complex subunit organization
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
anatomical structure homeostasis