TFPT [The Human Chemical-Genetic Interaction Map Project]

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======= TFPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFPT
  * **<color #00a2e8>Official Name</color>**: TCF3 fusion partner
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29844|29844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C1Z6|P0C1Z6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609519|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to promote apoptosis in a p53/TP53-independent manner.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|DNA recombination|
|nuclear membrane|
|protein deubiquitination|
|apoptotic signaling pathway|
|protein modification by small protein removal|
|DNA repair|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|programmed cell death|
|cell death|
|proteolysis|
|DNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.77|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.53|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.48|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.34|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.25|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.08|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.94|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.92|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.87|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.86|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.84|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.78|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.73|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.73|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.72|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.78|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.8|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.81|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.83|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.93|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.16|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.31|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.35|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.83|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.92|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|4.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ino80e|INO80E]]|0.648|
|[[:human genes:n:nfrkb|NFRKB]]|0.614|
|[[:human genes:u:uchl5|UCHL5]]|0.578|
|[[:human genes:m:mbtd1|MBTD1]]|0.479|
|[[:human genes:p:pih1d1|PIH1D1]]|0.426|
|[[:human genes:i:ino80|INO80]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3066
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFPT Expression in NALM6 Cells: 3.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>