TFPT

Entrez Summary: N/A
UniProt Summary: Appears to promote apoptosis in a p53/TP53-independent manner.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN racemic mixture R03 exp93	-2.77
Rotenone 20μM R00 exp34	-2.53
TRAIL 5ng/ml R00 exp35	-2.48
Trimetrexate 0.03μM R08 exp535	-2.34
Tozasertib 0.1μM R07 exp414	-2.25
Diepoxybutane 3μM R07 exp354	-2.08
Aphidicolin 0.4μM R08 exp440	-1.94
Bortezomib 0.005μM R00 exp6	-1.92
Erlotinib 10μM R05 exp216	-1.87
Vinblastine 0.2μM R03 exp108	-1.86
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.84
All-trans-Retinoic-Acid 40μM R07 exp334	-1.78
CR131-b 0.005μM R08 exp474	-1.78
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.73
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.73
AICAR 240μM R03 exp116	-1.72
D-Fructose 10000μM R06 exp279	1.78
Rapamycin 2μM R07 exp306	1.8
I-BRD9 4μM R07 exp365	1.81
EPZ-5676 30μM R05 exp233	1.83
LY2090314 0.003μM R08 exp500 no dilution day6	1.93
THZ531 0.11μM R07 exp409	2.16
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.31
ML-792 0.2μM R08 exp505	2.35
THZ531 0.225μM R08 exp444	2.73
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.83
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.92
Tubacin 1.6μM R07 exp416	4.55

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ino80 complex
DNA recombination
nuclear membrane
protein deubiquitination
apoptotic signaling pathway
protein modification by small protein removal
DNA repair
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
DNA metabolic process
cellular response to DNA damage stimulus
apoptotic process
protein modification by small protein conjugation or removal
programmed cell death
cell death
proteolysis
DNA binding
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
cellular response to stress