TGFA [The Human Chemical-Genetic Interaction Map Project]

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======= TGFA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFA
  * **<color #00a2e8>Official Name</color>**: transforming growth factor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7039|7039]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01135|P01135]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of epidermal growth factor-activated receptor activity|
|regulation of epidermal growth factor-activated receptor activity|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of ERBB signaling pathway|
|epidermal growth factor receptor binding|
|positive regulation of signaling receptor activity|
|negative regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|clathrin-coated vesicle membrane|
|positive regulation of mitotic nuclear division|
|ER to Golgi transport vesicle membrane|
|positive regulation of protein tyrosine kinase activity|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|positive regulation of nuclear division|
|vesicle coating|
|COPII-coated vesicle budding|
|ERBB signaling pathway|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of cell division|
|regulation of protein tyrosine kinase activity|
|vesicle targeting|
|regulation of ERBB signaling pathway|
|vesicle budding from membrane|
|positive regulation of mitotic cell cycle|
|activation of MAPK activity|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|regulation of mitotic nuclear division|
|regulation of signaling receptor activity|
|establishment of vesicle localization|
|vesicle localization|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|basolateral plasma membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein kinase B signaling|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|positive regulation of cell cycle process|
|vesicle organization|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|establishment of organelle localization|
|MAPK cascade|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|signal transduction by protein phosphorylation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|organelle localization|
|cell surface|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|perinuclear region of cytoplasm|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|membrane organization|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.7|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.7|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15611
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFA Expression in NALM6 Cells: 2.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>