TGFA

Gene Information

Official Symbol: TGFA
Official Name: transforming growth factor alpha
Aliases and Previous Symbols: N/A
Entrez ID: 7039
UniProt: P01135
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15611
Expression level (log2 read counts): 2.02

Expression Distribution

Screen	Score
Colchicine 0.009μM R05 exp215	-1.7
UM0011500 10μM R05 exp246	-1.7
GSK-J5 1.5μM R08 exp484	1.78

positive regulation of epidermal growth factor-activated receptor activity
regulation of epidermal growth factor-activated receptor activity
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERBB signaling pathway
epidermal growth factor receptor binding
positive regulation of signaling receptor activity
negative regulation of epidermal growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
clathrin-coated vesicle membrane
positive regulation of mitotic nuclear division
ER to Golgi transport vesicle membrane
positive regulation of protein tyrosine kinase activity
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
positive regulation of nuclear division
vesicle coating
COPII-coated vesicle budding
ERBB signaling pathway
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi vesicle budding
regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell division
regulation of protein tyrosine kinase activity
vesicle targeting
regulation of ERBB signaling pathway
vesicle budding from membrane
positive regulation of mitotic cell cycle
activation of MAPK activity
growth factor activity
positive regulation of protein kinase B signaling
regulation of cell division
regulation of mitotic nuclear division
regulation of signaling receptor activity
establishment of vesicle localization
vesicle localization
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of nuclear division