TGFBI

Entrez Summary: This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extracellular matrix binding
cell adhesion molecule binding
collagen binding
chondrocyte differentiation
basement membrane
integrin binding
extracellular matrix structural constituent
trans-Golgi network
cartilage development
visual perception
sensory perception of light stimulus
connective tissue development
extracellular matrix
negative regulation of cell adhesion
angiogenesis
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
blood vessel morphogenesis
blood vessel development
skeletal system development
vasculature development
cardiovascular system development
cell population proliferation
tube morphogenesis
regulation of cell adhesion
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
cell adhesion
biological adhesion
sensory perception
nervous system process
extracellular space
tissue development
extracellular region
system process