TGM1 [The Human Chemical-Genetic Interaction Map Project]

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======= TGM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGM1
  * **<color #00a2e8>Official Name</color>**: transglutaminase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7051|7051]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22735|P22735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190195|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transglut C|
|Transglut core|
|Transglut N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|external encapsulating structure organization|
|cell envelope organization|
|protein-glutamine gamma-glutamyltransferase activity|
|positive regulation of keratinocyte proliferation|
|intrinsic component of membrane|
|regulation of keratinocyte proliferation|
|peptide cross-linking|
|cornified envelope|
|cornification|
|positive regulation of epithelial cell proliferation|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regulation of epithelial cell proliferation|
|positive regulation of cell cycle|
|skin development|
|epidermis development|
|epithelial cell differentiation|
|positive regulation of cell population proliferation|
|programmed cell death|
|cell death|
|epithelium development|
|regulation of cell cycle|
|regulation of cell population proliferation|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.71|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.16|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5164
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGM1 Expression in NALM6 Cells: 1.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>