TGM1
Gene Information
- Official Symbol: TGM1
- Official Name: transglutaminase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7051
- UniProt: P22735
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008].
- UniProt Summary: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5164
- Expression level (log2 read counts): 1.09
TGM1 Expression in NALM6 Cells: 1.09
