TGM5 [The Human Chemical-Genetic Interaction Map Project]

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======= TGM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGM5
  * **<color #00a2e8>Official Name</color>**: transglutaminase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9333|9333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43548|O43548]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transglut N|
|Transglut core|
|Transglut C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-glutamine gamma-glutamyltransferase activity|
|peptide cross-linking|
|cornification|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|skin development|
|epidermis development|
|epithelial cell differentiation|
|programmed cell death|
|cell death|
|epithelium development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.72|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.479|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.472|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.445|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.44|
|[[:human genes:o:or10g3|OR10G3]]|0.434|
|[[:human genes:t:tfip11|TFIP11]]|0.427|
|[[:human genes:t:tceb3c|TCEB3C]]|0.424|
|[[:human genes:n:nol10|NOL10]]|0.422|
|[[:human genes:n:nup43|NUP43]]|0.419|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.419|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.417|
|[[:human genes:p:psmd11|PSMD11]]|0.417|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.412|
|[[:human genes:r:rps12|RPS12]]|0.412|
|[[:human genes:r:rbm39|RBM39]]|0.411|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.41|
|[[:human genes:p:polr2a|POLR2A]]|0.409|
|[[:human genes:o:orc6|ORC6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGM5 Expression in NALM6 Cells: -0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>