TH
Gene Information
- Official Symbol: TH
- Official Name: tyrosine hydroxylase
- Aliases and Previous Symbols: N/A
- Entrez ID: 7054
- UniProt: P07101
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| TOH N |
| Biopterin H |
GO Terms
| tyrosine 3-monooxygenase activity |
| dopamine biosynthetic process from tyrosine |
| phytoalexin metabolic process |
| epinephrine biosynthetic process |
| phthalate metabolic process |
| isoquinoline alkaloid metabolic process |
| terpene metabolic process |
| epinephrine metabolic process |
| aminergic neurotransmitter loading into synaptic vesicle |
| tetrahydrobiopterin binding |
| response to pyrethroid |
| circadian sleep/wake cycle |
| response to isolation stress |
| alkaloid metabolic process |
| amine transport |
| norepinephrine biosynthetic process |
| neurotransmitter loading into synaptic vesicle |
| response to water deprivation |
| cellular response to nicotine |
| dopamine biosynthetic process |
| tyrosine metabolic process |
| ferric iron binding |
| cellular response to manganese ion |
| response to ether |
| norepinephrine metabolic process |
| response to herbicide |
| dopamine binding |
| melanosome membrane |
| response to water |
| response to insecticide |
| amino acid binding |
| response to manganese ion |
| catechol-containing compound biosynthetic process |
| catecholamine biosynthetic process |
| synaptic transmission, dopaminergic |
| response to corticosterone |
| glycoside metabolic process |
| mating behavior |
| circadian behavior |
| response to salt stress |
| toxin metabolic process |
| ferrous iron binding |
| rhythmic behavior |
| benzene-containing compound metabolic process |
| embryonic camera-type eye morphogenesis |
| response to immobilization stress |
| smooth endoplasmic reticulum |
| dopamine metabolic process |
| reproductive behavior |
| eating behavior |
| response to mineralocorticoid |
| response to amphetamine |
| oxygen binding |
| mating |
| phenol-containing compound biosynthetic process |
| eye photoreceptor cell development |
| embryonic eye morphogenesis |
| multicellular organism aging |
| cellular response to alkaloid |
| embryonic camera-type eye development |
| aromatic amino acid family metabolic process |
| neurotransmitter biosynthetic process |
| response to electrical stimulus |
| catecholamine metabolic process |
| catechol-containing compound metabolic process |
| eye photoreceptor cell differentiation |
| response to amine |
| photoreceptor cell development |
| terminal bouton |
| response to nicotine |
| response to bronchodilator |
| intraspecies interaction between organisms |
| social behavior |
| cytoplasmic side of plasma membrane |
| response to zinc ion |
| secondary metabolic process |
| photoreceptor cell differentiation |
| response to activity |
| multi-organism behavior |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| response to osmotic stress |
| cellular response to carbohydrate stimulus |
| phenol-containing compound metabolic process |
| feeding behavior |
| cellular glucose homeostasis |
| neurotransmitter metabolic process |
| pigmentation |
| dicarboxylic acid metabolic process |
| response to alkaloid |
| camera-type eye morphogenesis |
| cerebral cortex development |
| memory |
| synaptic vesicle cycle |
| synaptic vesicle |
| response to ethanol |
| vesicle-mediated transport in synapse |
| glycosyl compound metabolic process |
| perikaryon |
| response to estradiol |
| response to glucose |
| isoprenoid metabolic process |
| circadian rhythm |
| response to hexose |
| response to glucocorticoid |
| sensory perception of sound |
| learning |
| eye morphogenesis |
| response to monosaccharide |
| sphingolipid metabolic process |
| response to corticosteroid |
| sensory perception of mechanical stimulus |
| response to carbohydrate |
| pallium development |
| neurotransmitter transport |
| glucose homeostasis |
| organic hydroxy compound biosynthetic process |
| carbohydrate homeostasis |
| cellular response to metal ion |
| ammonium ion metabolic process |
| response to ketone |
| locomotory behavior |
| membrane lipid metabolic process |
| alpha-amino acid metabolic process |
| cellular response to toxic substance |
| cellular response to inorganic substance |
| visual perception |
| sensory perception of light stimulus |
| response to alcohol |
| regulation of heart contraction |
| protein domain specific binding |
| heart morphogenesis |
| cytoplasmic vesicle |
| sensory organ morphogenesis |
| telencephalon development |
| learning or memory |
| rhythmic process |
| aging |
| regulation of blood circulation |
| embryonic organ morphogenesis |
| axon |
| cognition |
| response to xenobiotic stimulus |
| response to antibiotic |
| response to light stimulus |
| cellular amino acid metabolic process |
| camera-type eye development |
| response to lipopolysaccharide |
| neuron projection |
| fatty acid metabolic process |
| response to molecule of bacterial origin |
| response to steroid hormone |
| response to hypoxia |
| response to acid chemical |
| enzyme binding |
| regulation of neurotransmitter levels |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| sensory system development |
| response to metal ion |
| response to oxygen levels |
| forebrain development |
| response to peptide hormone |
| cellular response to drug |
| chemical synaptic transmission |
| dendrite |
| anterograde trans-synaptic signaling |
| embryonic organ development |
| trans-synaptic signaling |
| response to radiation |
| organic hydroxy compound metabolic process |
| synaptic signaling |
| response to peptide |
| response to nutrient levels |
| drug metabolic process |
| cellular response to growth factor stimulus |
| response to toxic substance |
| heart development |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| response to growth factor |
| response to inorganic substance |
| sensory organ development |
| embryonic morphogenesis |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| response to bacterium |
| brain development |
| cellular chemical homeostasis |
| head development |
| neuron development |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| circulatory system development |
| cellular homeostasis |
| response to hormone |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| oxidation-reduction process |
| sensory perception |
| embryo development |
| central nervous system development |
| multi-organism reproductive process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| neuron differentiation |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| response to abiotic stimulus |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| mitochondrion |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| nervous system process |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| generation of neurons |
| response to oxygen-containing compound |
| neurogenesis |
| homeostatic process |
| cell development |
| small molecule metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Etoposide 0.1μM R05 exp198 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4204
- Expression level (log2 read counts): -3.9
Expression Distribution
TH Expression in NALM6 Cells: -3.9
