THAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= THAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THAP1
  * **<color #00a2e8>Official Name</color>**: THAP domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55145|55145]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVV9|Q9NVV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|THAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell proliferation|
|epithelial cell proliferation|
|PML body|
|fibrillar center|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sequence-specific DNA binding|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell population proliferation|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|intracellular membrane-bounded organelle|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.74|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.52|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.36|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.27|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.25|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.99|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.89|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.81|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.81|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.8|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.78|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.71|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.99|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.11|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 653/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|17/28|
|bone|26/26|
|breast|27/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|18/21|
|liver|19/20|
|lung|68/75|
|lymphocyte|10/16|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4810
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THAP1 Expression in NALM6 Cells: 3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>