THAP1

Gene Information

Official Symbol: THAP1
Official Name: THAP domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 55145
UniProt: Q9NVV9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
UniProt Summary: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
INK128 0.2μM R02 exp70	-2.74
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.52
Bortezomib 0.005μM R00 exp6	-2.36
Bafilomycin-A1 0.009μM R08 exp454	-2.27
BI-2536 0.0042μM R03 exp95	-2.25
Mdivi-1 15μM R05 exp217	-1.99
Tunicamycin 0.04μM R07 exp418	-1.89
CVT-10216 0.1μM R06 exp278	-1.81
KU-0063794 3.8μM R02 exp71	-1.81
IU1-C 25μM R04 exp183	-1.8
Citral 50μM R06 exp274	-1.78
BI-6727 0.0125μM R03 exp97	-1.76
Thapsigargin 0.005μM R07 exp407	-1.71
LB-100 4.1μM R02 exp72	-1.7
ML-792 0.2μM R08 exp505	1.8
NFN1 0.1μM R01 exp49	1.99
MLN-4924 0.2μM R00 exp21	2.11
Lapatinib 5μM R01 exp47	3.45

Global Fraction of Cell Lines Where Essential: 653/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	25/28
blood	17/28
bone	26/26
breast	27/33
central nervous system	50/56
cervix	4/4
colorectal	17/17
esophagus	11/13
fibroblast	1/1
gastric	14/16
kidney	18/21
liver	19/20
lung	68/75
lymphocyte	10/16
ovary	23/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	24/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 4810
Expression level (log2 read counts): 3.21

Expression Distribution

endothelial cell proliferation
epithelial cell proliferation
PML body
fibrillar center
DNA-binding transcription repressor activity, RNA polymerase II-specific
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
cell population proliferation
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
intracellular membrane-bounded organelle
zinc ion binding
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
macromolecule biosynthetic process
gene expression