THAP4

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-2.69
JQ1 0.8μM R08 exp435	-2.3
Doxorubicin 0.02μM R08 exp478	-1.82
Cannabidiol 13μM R08 exp465	-1.71
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

THAP
DUF1794

heme binding
cellular component
protein homodimerization activity
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific