THEM4

Entrez Summary: N/A
UniProt Summary: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myristoyl-CoA hydrolase activity
palmitoyl-CoA hydrolase activity
regulation of mitochondrial membrane permeability involved in apoptotic process
protein kinase B signaling
negative regulation of protein kinase B signaling
apoptotic mitochondrial changes
regulation of mitochondrial membrane permeability
mitochondrial intermembrane space
regulation of membrane permeability
ruffle membrane
thioester metabolic process
acyl-CoA metabolic process
mitochondrial membrane organization
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
mitochondrial transport
regulation of protein kinase B signaling
coenzyme metabolic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
mitochondrial matrix
mitochondrial inner membrane
cofactor metabolic process
mitochondrion organization
nucleotide metabolic process
nucleoside phosphate metabolic process
negative regulation of intracellular signal transduction
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
cellular amide metabolic process
membrane organization
organophosphate metabolic process
carboxylic acid metabolic process
apoptotic process