THEMIS

Entrez Summary: This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative T cell selection
positive T cell selection
COP9 signalosome
T cell selection
T cell differentiation
cell-cell junction
T cell receptor signaling pathway
T cell activation
lymphocyte differentiation
antigen receptor-mediated signaling pathway
leukocyte differentiation
lymphocyte activation
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway
hematopoietic or lymphoid organ development
adaptive immune response
activation of immune response
immune system development
positive regulation of immune response
leukocyte activation
cell activation
regulation of immune response
positive regulation of immune system process
regulation of immune system process
immune response