THG1L [The Human Chemical-Genetic Interaction Map Project]

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======= THG1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THG1L
  * **<color #00a2e8>Official Name</color>**: tRNA-histidine guanylyltransferase 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54974|54974]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWX6|Q9NWX6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THG1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THG1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618802|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. {ECO:0000269|PubMed:21059936}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thg1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA guanylyltransferase activity|
|nucleotidyltransferase activity|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|tRNA binding|
|tRNA modification|
|protein homotetramerization|
|tRNA processing|
|protein tetramerization|
|RNA modification|
|tRNA metabolic process|
|magnesium ion binding|
|protein homooligomerization|
|ncRNA processing|
|GTP binding|
|ncRNA metabolic process|
|protein complex oligomerization|
|RNA processing|
|identical protein binding|
|mitochondrion|
|ATP binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.17|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.14|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.98|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.94|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.86|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.86|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.84|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.82|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.82|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.76|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.71|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.71|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.72|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.72|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.73|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.74|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.82|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.83|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.84|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.85|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.01|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.06|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.09|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.1|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.11|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.16|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.2|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.23|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.28|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.33|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.33|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.35|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.4|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.47|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.5|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.58|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.59|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.6|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.6|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.73|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.79|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.86|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.19|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|3.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|3.25|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|3.36|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpagt1|DPAGT1]]|0.76|
|[[:human genes:p:pmm2|PMM2]]|0.754|
|[[:human genes:a:alg1|ALG1]]|0.749|
|[[:human genes:d:dohh|DOHH]]|0.748|
|[[:human genes:r:rptor|RPTOR]]|0.747|
|[[:human genes:a:atxn10|ATXN10]]|0.742|
|[[:human genes:g:gmppb|GMPPB]]|0.725|
|[[:human genes:u:uap1|UAP1]]|0.72|
|[[:human genes:r:rtcb|RTCB]]|0.718|
|[[:human genes:r:rnmt|RNMT]]|0.717|
|[[:human genes:t:triap1|TRIAP1]]|0.715|
|[[:human genes:g:gfpt1|GFPT1]]|0.711|
|[[:human genes:r:rpp21|RPP21]]|0.704|
|[[:human genes:v:vezt|VEZT]]|0.695|
|[[:human genes:a:adsl|ADSL]]|0.676|
|[[:human genes:d:dr1|DR1]]|0.672|
|[[:human genes:s:srp14|SRP14]]|0.671|
|[[:human genes:p:ppcs|PPCS]]|0.662|
|[[:human genes:e:exoc4|EXOC4]]|0.659|
|[[:human genes:d:dhps|DHPS]]|0.656|
|[[:human genes:o:oraov1|ORAOV1]]|0.655|
|[[:human genes:u:uhrf1|UHRF1]]|0.647|
|[[:human genes:t:ttc4|TTC4]]|0.645|
|[[:human genes:m:med16|MED16]]|0.638|
|[[:human genes:t:tsen54|TSEN54]]|0.637|
|[[:human genes:p:pelo|PELO]]|0.634|
|[[:human genes:a:atic|ATIC]]|0.634|
|[[:human genes:t:trnt1|TRNT1]]|0.629|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.628|
|[[:human genes:f:fh|FH]]|0.627|
|[[:human genes:a:alg13|ALG13]]|0.627|
|[[:human genes:n:nae1|NAE1]]|0.626|
|[[:human genes:t:ten1|TEN1]]|0.626|
|[[:human genes:u:utp23|UTP23]]|0.625|
|[[:human genes:g:gemin6|GEMIN6]]|0.624|
|[[:human genes:s:slc25a26|SLC25A26]]|0.621|
|[[:human genes:a:alg2|ALG2]]|0.618|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.615|
|[[:human genes:a:atp5j|ATP5J]]|0.613|
|[[:human genes:r:rft1|RFT1]]|0.611|
|[[:human genes:k:kdsr|KDSR]]|0.609|
|[[:human genes:s:slc25a19|SLC25A19]]|0.604|
|[[:human genes:u:urm1|URM1]]|0.603|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.602|
|[[:human genes:r:romo1|ROMO1]]|0.601|
|[[:human genes:e:elp2|ELP2]]|0.599|
|[[:human genes:g:gnb1l|GNB1L]]|0.597|
|[[:human genes:h:hccs|HCCS]]|0.596|
|[[:human genes:h:hspd1|HSPD1]]|0.594|
|[[:human genes:d:ddx20|DDX20]]|0.594|
|[[:human genes:b:bap1|BAP1]]|0.593|
|[[:human genes:g:gemin7|GEMIN7]]|0.593|
|[[:human genes:d:dolk|DOLK]]|0.593|
|[[:human genes:g:gemin8|GEMIN8]]|0.592|
|[[:human genes:r:rpia|RPIA]]|0.592|
|[[:human genes:d:ddx1|DDX1]]|0.591|
|[[:human genes:e:elp3|ELP3]]|0.59|
|[[:human genes:t:trmt5|TRMT5]]|0.589|
|[[:human genes:b:bak1|BAK1]]|0.589|
|[[:human genes:c:casp9|CASP9]]|0.589|
|[[:human genes:t:tti2|TTI2]]|0.588|
|[[:human genes:m:mtor|MTOR]]|0.587|
|[[:human genes:t:trmt10a|TRMT10A]]|0.586|
|[[:human genes:z:zrsr2|ZRSR2]]|0.586|
|[[:human genes:t:trmt61a|TRMT61A]]|0.586|
|[[:human genes:e:eny2|ENY2]]|0.583|
|[[:human genes:d:dnlz|DNLZ]]|0.582|
|[[:human genes:p:plaa|PLAA]]|0.58|
|[[:human genes:w:wdr24|WDR24]]|0.577|
|[[:human genes:a:atp5o|ATP5O]]|0.575|
|[[:human genes:s:ssb|SSB]]|0.573|
|[[:human genes:w:wdr59|WDR59]]|0.57|
|[[:human genes:t:tamm41|TAMM41]]|0.57|
|[[:human genes:r:rpe|RPE]]|0.569|
|[[:human genes:l:lsm11|LSM11]]|0.567|
|[[:human genes:o:osgep|OSGEP]]|0.566|
|[[:human genes:t:tprkb|TPRKB]]|0.564|
|[[:human genes:p:ppa2|PPA2]]|0.563|
|[[:human genes:t:tbca|TBCA]]|0.563|
|[[:human genes:m:med4|MED4]]|0.563|
|[[:human genes:p:pdap1|PDAP1]]|0.563|
|[[:human genes:t:tsen34|TSEN34]]|0.563|
|[[:human genes:r:rfk|RFK]]|0.561|
|[[:human genes:a:atp5b|ATP5B]]|0.561|
|[[:human genes:u:uba3|UBA3]]|0.56|
|[[:human genes:p:ppp6c|PPP6C]]|0.56|
|[[:human genes:h:haus8|HAUS8]]|0.559|
|[[:human genes:c:cbfb|CBFB]]|0.558|
|[[:human genes:e:exoc3|EXOC3]]|0.558|
|[[:human genes:u:ube2g2|UBE2G2]]|0.557|
|[[:human genes:a:apaf1|APAF1]]|0.556|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.555|
|[[:human genes:d:dhrsx|DHRSX]]|0.553|
|[[:human genes:c:cep57|CEP57]]|0.553|
|[[:human genes:t:taz|TAZ]]|0.55|
|[[:human genes:d:ddx55|DDX55]]|0.549|
|[[:human genes:a:alg6|ALG6]]|0.548|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.548|
|[[:human genes:p:polr3h|POLR3H]]|0.547|
|[[:human genes:l:lsm10|LSM10]]|0.547|
|[[:human genes:t:txnrd1|TXNRD1]]|0.547|
|[[:human genes:r:rabggtb|RABGGTB]]|0.546|
|[[:human genes:f:faf2|FAF2]]|0.546|
|[[:human genes:e:eef1e1|EEF1E1]]|0.545|
|[[:human genes:c:csnk2b|CSNK2B]]|0.543|
|[[:human genes:t:tpk1|TPK1]]|0.543|
|[[:human genes:d:ddx39a|DDX39A]]|0.54|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.539|
|[[:human genes:y:yars|YARS]]|0.539|
|[[:human genes:t:tbcb|TBCB]]|0.539|
|[[:human genes:c:ccdc101|CCDC101]]|0.538|
|[[:human genes:e:eif4e|EIF4E]]|0.537|
|[[:human genes:e:elac2|ELAC2]]|0.537|
|[[:human genes:c:c15orf41|C15orf41]]|0.536|
|[[:human genes:a:atp2a2|ATP2A2]]|0.534|
|[[:human genes:t:timm13|TIMM13]]|0.533|
|[[:human genes:v:vhl|VHL]]|0.532|
|[[:human genes:c:chchd4|CHCHD4]]|0.532|
|[[:human genes:t:telo2|TELO2]]|0.532|
|[[:human genes:f:fnta|FNTA]]|0.531|
|[[:human genes:p:ppp4c|PPP4C]]|0.531|
|[[:human genes:d:dad1|DAD1]]|0.529|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.528|
|[[:human genes:n:n6amt1|N6AMT1]]|0.528|
|[[:human genes:n:nsd1|NSD1]]|0.527|
|[[:human genes:t:tti1|TTI1]]|0.527|
|[[:human genes:t:tmem41b|TMEM41B]]|0.525|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.525|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.524|
|[[:human genes:c:cct7|CCT7]]|0.521|
|[[:human genes:b:bcs1l|BCS1L]]|0.521|
|[[:human genes:a:alg14|ALG14]]|0.519|
|[[:human genes:e:eif3f|EIF3F]]|0.518|
|[[:human genes:w:wdr92|WDR92]]|0.518|
|[[:human genes:t:txnl4b|TXNL4B]]|0.515|
|[[:human genes:u:ubqln1|UBQLN1]]|0.514|
|[[:human genes:e:eno1|ENO1]]|0.514|
|[[:human genes:t:tmem242|TMEM242]]|0.512|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.512|
|[[:human genes:a:aars|AARS]]|0.512|
|[[:human genes:w:wdr82|WDR82]]|0.51|
|[[:human genes:d:ddost|DDOST]]|0.51|
|[[:human genes:u:uxt|UXT]]|0.51|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.51|
|[[:human genes:e:eprs|EPRS]]|0.508|
|[[:human genes:s:snapc5|SNAPC5]]|0.508|
|[[:human genes:a:alg5|ALG5]]|0.507|
|[[:human genes:c:ctc1|CTC1]]|0.505|
|[[:human genes:a:atp5a1|ATP5A1]]|0.502|
|[[:human genes:s:sec61g|SEC61G]]|0.502|
|[[:human genes:b:bub3|BUB3]]|0.502|
|[[:human genes:m:mbtps2|MBTPS2]]|0.501|
|[[:human genes:r:rpn1|RPN1]]|0.501|
|[[:human genes:t:tgs1|TGS1]]|0.501|
|[[:human genes:c:crcp|CRCP]]|0.499|
|[[:human genes:n:nbn|NBN]]|0.499|
|[[:human genes:s:sec62|SEC62]]|0.499|
|[[:human genes:z:zzz3|ZZZ3]]|0.499|
|[[:human genes:s:srd5a3|SRD5A3]]|0.498|
|[[:human genes:c:crls1|CRLS1]]|0.498|
|[[:human genes:p:pam16|PAM16]]|0.497|
|[[:human genes:c:cmtr1|CMTR1]]|0.496|
|[[:human genes:d:dpf2|DPF2]]|0.496|
|[[:human genes:m:mocs3|MOCS3]]|0.495|
|[[:human genes:y:yars2|YARS2]]|0.493|
|[[:human genes:m:mis18a|MIS18A]]|0.492|
|[[:human genes:a:atp5d|ATP5D]]|0.49|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.487|
|[[:human genes:p:ppcdc|PPCDC]]|0.487|
|[[:human genes:v:vdac2|VDAC2]]|0.487|
|[[:human genes:o:oip5|OIP5]]|0.486|
|[[:human genes:t:taf1a|TAF1A]]|0.484|
|[[:human genes:e:eif1ax|EIF1AX]]|0.484|
|[[:human genes:s:srp72|SRP72]]|0.483|
|[[:human genes:p:pgm3|PGM3]]|0.482|
|[[:human genes:c:cycs|CYCS]]|0.481|
|[[:human genes:s:serf2|SERF2]]|0.48|
|[[:human genes:c:c14orf166|C14orf166]]|0.48|
|[[:human genes:p:polr3b|POLR3B]]|0.479|
|[[:human genes:c:c14orf80|C14orf80]]|0.478|
|[[:human genes:m:med23|MED23]]|0.478|
|[[:human genes:d:dars2|DARS2]]|0.477|
|[[:human genes:p:pgs1|PGS1]]|0.476|
|[[:human genes:c:cdipt|CDIPT]]|0.476|
|[[:human genes:t:trim28|TRIM28]]|0.473|
|[[:human genes:m:msto1|MSTO1]]|0.473|
|[[:human genes:z:zbtb11|ZBTB11]]|0.472|
|[[:human genes:g:gtf3a|GTF3A]]|0.47|
|[[:human genes:s:sdha|SDHA]]|0.47|
|[[:human genes:t:tbp|TBP]]|0.47|
|[[:human genes:c:c17orf89|C17orf89]]|0.47|
|[[:human genes:m:meaf6|MEAF6]]|0.468|
|[[:human genes:t:trmt6|TRMT6]]|0.468|
|[[:human genes:c:chordc1|CHORDC1]]|0.467|
|[[:human genes:u:ube2k|UBE2K]]|0.467|
|[[:human genes:m:mrps14|MRPS14]]|0.466|
|[[:human genes:w:wdr1|WDR1]]|0.466|
|[[:human genes:c:c1d|C1D]]|0.464|
|[[:human genes:c:ctu1|CTU1]]|0.463|
|[[:human genes:l:lsmd1|LSMD1]]|0.462|
|[[:human genes:r:rad50|RAD50]]|0.462|
|[[:human genes:s:spcs2|SPCS2]]|0.462|
|[[:human genes:d:dicer1|DICER1]]|0.461|
|[[:human genes:a:atp5h|ATP5H]]|0.461|
|[[:human genes:e:ercc2|ERCC2]]|0.46|
|[[:human genes:s:srp68|SRP68]]|0.46|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.46|
|[[:human genes:p:pggt1b|PGGT1B]]|0.459|
|[[:human genes:t:timm22|TIMM22]]|0.459|
|[[:human genes:g:gemin5|GEMIN5]]|0.459|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.457|
|[[:human genes:p:pik3r4|PIK3R4]]|0.456|
|[[:human genes:s:seh1l|SEH1L]]|0.456|
|[[:human genes:u:ube2m|UBE2M]]|0.456|
|[[:human genes:e:eftud1|EFTUD1]]|0.456|
|[[:human genes:m:mrps34|MRPS34]]|0.456|
|[[:human genes:m:mapk14|MAPK14]]|0.455|
|[[:human genes:m:mlst8|MLST8]]|0.455|
|[[:human genes:s:srprb|SRPRB]]|0.454|
|[[:human genes:m:metap2|METAP2]]|0.454|
|[[:human genes:s:snf8|SNF8]]|0.453|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.453|
|[[:human genes:n:naf1|NAF1]]|0.452|
|[[:human genes:n:nars|NARS]]|0.452|
|[[:human genes:z:znf608|ZNF608]]|0.451|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.451|
|[[:human genes:n:nsmce1|NSMCE1]]|0.451|
|[[:human genes:k:kdm8|KDM8]]|0.45|
|[[:human genes:v:vmp1|VMP1]]|0.45|
|[[:human genes:d:dctn6|DCTN6]]|0.449|
|[[:human genes:m:mfn1|MFN1]]|0.449|
|[[:human genes:p:pdss1|PDSS1]]|0.449|
|[[:human genes:m:march5|MARCH5]]|0.448|
|[[:human genes:c:cept1|CEPT1]]|0.447|
|[[:human genes:e:elp6|ELP6]]|0.444|
|[[:human genes:p:polr3c|POLR3C]]|0.444|
|[[:human genes:d:dctn5|DCTN5]]|0.444|
|[[:human genes:f:fen1|FEN1]]|0.443|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.443|
|[[:human genes:z:zcrb1|ZCRB1]]|0.443|
|[[:human genes:t:thoc6|THOC6]]|0.443|
|[[:human genes:t:tkt|TKT]]|0.442|
|[[:human genes:s:ssbp2|SSBP2]]|0.442|
|[[:human genes:c:c21orf59|C21orf59]]|0.441|
|[[:human genes:g:gpn2|GPN2]]|0.44|
|[[:human genes:p:pdpk1|PDPK1]]|0.44|
|[[:human genes:r:rbm14|RBM14]]|0.44|
|[[:human genes:s:sars2|SARS2]]|0.439|
|[[:human genes:t:taf11|TAF11]]|0.438|
|[[:human genes:c:cbx3|CBX3]]|0.437|
|[[:human genes:r:rad1|RAD1]]|0.437|
|[[:human genes:u:uba5|UBA5]]|0.437|
|[[:human genes:c:cinp|CINP]]|0.437|
|[[:human genes:r:rbfa|RBFA]]|0.437|
|[[:human genes:c:cox16|COX16]]|0.435|
|[[:human genes:d:dusp12|DUSP12]]|0.434|
|[[:human genes:z:znhit1|ZNHIT1]]|0.434|
|[[:human genes:k:kctd5|KCTD5]]|0.433|
|[[:human genes:n:naa20|NAA20]]|0.432|
|[[:human genes:g:gtf2h3|GTF2H3]]|0.432|
|[[:human genes:g:gatc|GATC]]|0.432|
|[[:human genes:d:dhdds|DHDDS]]|0.432|
|[[:human genes:l:lmo2|LMO2]]|0.432|
|[[:human genes:h:hars|HARS]]|0.431|
|[[:human genes:t:tubd1|TUBD1]]|0.431|
|[[:human genes:m:mllt1|MLLT1]]|0.43|
|[[:human genes:v:vrk1|VRK1]]|0.429|
|[[:human genes:t:tma16|TMA16]]|0.429|
|[[:human genes:u:uqcr10|UQCR10]]|0.428|
|[[:human genes:m:mrps33|MRPS33]]|0.428|
|[[:human genes:o:obfc1|OBFC1]]|0.428|
|[[:human genes:p:phb|PHB]]|0.427|
|[[:human genes:r:rbmx2|RBMX2]]|0.427|
|[[:human genes:p:pdcd5|PDCD5]]|0.427|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.427|
|[[:human genes:c:cox5a|COX5A]]|0.426|
|[[:human genes:m:mrpl21|MRPL21]]|0.426|
|[[:human genes:u:uso1|USO1]]|0.425|
|[[:human genes:t:tufm|TUFM]]|0.425|
|[[:human genes:r:rad23b|RAD23B]]|0.423|
|[[:human genes:t:tube1|TUBE1]]|0.421|
|[[:human genes:a:asxl2|ASXL2]]|0.421|
|[[:human genes:a:atp5f1|ATP5F1]]|0.42|
|[[:human genes:m:mrps18a|MRPS18A]]|0.42|
|[[:human genes:t:tmed10|TMED10]]|0.42|
|[[:human genes:s:slc35b1|SLC35B1]]|0.419|
|[[:human genes:m:mrps5|MRPS5]]|0.419|
|[[:human genes:v:vps41|VPS41]]|0.419|
|[[:human genes:f:fntb|FNTB]]|0.418|
|[[:human genes:g:g6pd|G6PD]]|0.418|
|[[:human genes:d:dap3|DAP3]]|0.417|
|[[:human genes:m:mrps16|MRPS16]]|0.417|
|[[:human genes:p:ptar1|PTAR1]]|0.417|
|[[:human genes:t:timm10|TIMM10]]|0.417|
|[[:human genes:i:id3|ID3]]|0.416|
|[[:human genes:a:abcf1|ABCF1]]|0.416|
|[[:human genes:e:exoc5|EXOC5]]|0.415|
|[[:human genes:x:xrcc2|XRCC2]]|0.415|
|[[:human genes:s:spr|SPR]]|0.414|
|[[:human genes:c:ciao1|CIAO1]]|0.414|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.414|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.413|
|[[:human genes:b:btaf1|BTAF1]]|0.411|
|[[:human genes:m:mars|MARS]]|0.41|
|[[:human genes:s:srrd|SRRD]]|0.41|
|[[:human genes:d:dph3|DPH3]]|0.409|
|[[:human genes:a:actr10|ACTR10]]|0.408|
|[[:human genes:f:fbxo11|FBXO11]]|0.406|
|[[:human genes:m:mrps6|MRPS6]]|0.406|
|[[:human genes:e:elp4|ELP4]]|0.405|
|[[:human genes:o:opa1|OPA1]]|0.405|
|[[:human genes:r:rabif|RABIF]]|0.405|
|[[:human genes:a:atp5i|ATP5I]]|0.404|
|[[:human genes:r:rpusd4|RPUSD4]]|0.403|
|[[:human genes:z:znf259|ZNF259]]|0.403|
|[[:human genes:m:mrps2|MRPS2]]|0.402|
|[[:human genes:t:thoc3|THOC3]]|0.401|
|[[:human genes:s:sgol1|SGOL1]]|0.401|
|[[:human genes:t:tpi1|TPI1]]|0.4|
|[[:human genes:a:atm|ATM]]|0.4|
|[[:human genes:t:tomm22|TOMM22]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 159/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|3/28|
|bone|10/26|
|breast|2/33|
|central nervous system|15/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|7/21|
|liver|11/20|
|lung|19/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 441
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THG1L Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>