THG1L

Gene Information

Official Symbol: THG1L
Official Name: tRNA-histidine guanylyltransferase 1 like
Aliases and Previous Symbols: N/A
Entrez ID: 54974
UniProt: Q9NWX6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. {ECO:0000269|PubMed:21059936}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 25μM plus proTAME 2μM R04 exp177	-2.17
S-DABN 8μM R03 exp112	-2.14
Wiskostatin 3μM R07 exp422	-1.98
A-769662 20μM R07 exp331	-1.94
A-366 10μM R03 exp115	-1.86
NFN1 0.1μM R01 exp49	-1.86
Beta-Estradiol 0.55μM R07 exp425	-1.84
ABT-702 0.1μM R06 exp260	-1.82
UM131593 0.1μM R01 exp58	-1.82
PNU96415E 10μM R03 exp145	-1.76
CAY10603 0.55μM R08 exp467	-1.71
Adefovir 20μM R07 exp332	-1.71
AICAR 240μM R05 exp211	1.72
RO-3307 4.7μM R02 exp80	1.72
5-Fluorouracil 20μM R00 exp2	1.73
Pimelic-diphenylamide-106 5μM R00 exp28	1.74
Cryptotanshinone 12μM R05 exp227	1.82
Nocodazole 0.2μM R00 exp24	1.83
BVD-523 15μM R02 exp67	1.84
ONC212 0.15μM R08 exp513	1.85
Doxorubicin 0.02μM R08 exp478	2.01
Nocodazole 0.1μM R03 exp94	2.06
Vinblastine 0.2μM R03 exp108	2.09
R-DABN 8μM R03 exp111	2.1
Artemisinin 50μM R08 exp450	2.11
TIC10 10μM R08 exp532	2.16
Thimerosal 0.85μM R08 exp529	2.2
JQ1 0.8μM R08 exp435	2.23
SNS-032 15μM R08 exp443	2.28
Aphidicolin 0.4μM R08 exp440	2.33
Deferoxamine 11μM R07 exp350	2.33
Etoposide 0.3μM R05 exp199	2.35
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.4
Staurosporine 0.02μM R08 exp524	2.47
Atovaquone 15μM R08 exp451	2.5
DABN racemic mixture R03 exp93	2.58
CI-1040 9.5μM R08 exp472	2.59
THZ1 0.06μM R08 exp531	2.6
UM0129480 7μM R02 exp85	2.6
Hinokiflavone 12μM R08 exp487	2.73
Mitomycin-C 0.06μM R08 exp503	2.79
MS023 7μM R03 exp135	2.79
Bleomycin 5μM R08 exp459	2.86
Benzoate 20000μM R08 exp456	3.19
BI-2536 0.02μM R03 exp96	3.2
PU-H71 1μM R08 exp515	3.25
BI-6727 0.04μM R03 exp98	3.36
GSK461364A 0.1μM R03 exp126	3.55

Gene	Correlation
DPAGT1	0.76
PMM2	0.754
ALG1	0.749
DOHH	0.748
RPTOR	0.747
ATXN10	0.742
GMPPB	0.725
UAP1	0.72
RTCB	0.718
RNMT	0.717
TRIAP1	0.715
GFPT1	0.711
RPP21	0.704
VEZT	0.695
ADSL	0.676
DR1	0.672
SRP14	0.671
PPCS	0.662
EXOC4	0.659
DHPS	0.656
ORAOV1	0.655
UHRF1	0.647
TTC4	0.645
MED16	0.638
TSEN54	0.637
PELO	0.634
ATIC	0.634
TRNT1	0.629
GTF3C3	0.628
FH	0.627
ALG13	0.627
NAE1	0.626
TEN1	0.626
UTP23	0.625
GEMIN6	0.624
SLC25A26	0.621
ALG2	0.618
GTF3C4	0.615
ATP5J	0.613
RFT1	0.611
KDSR	0.609
SLC25A19	0.604
URM1	0.603
GTF3C6	0.602
ROMO1	0.601
ELP2	0.599
GNB1L	0.597
HCCS	0.596
HSPD1	0.594
DDX20	0.594
BAP1	0.593
GEMIN7	0.593
DOLK	0.593
GEMIN8	0.592
RPIA	0.592
DDX1	0.591
ELP3	0.59
TRMT5	0.589
BAK1	0.589
CASP9	0.589
TTI2	0.588
MTOR	0.587
TRMT10A	0.586
ZRSR2	0.586
TRMT61A	0.586
ENY2	0.583
DNLZ	0.582
PLAA	0.58
WDR24	0.577
ATP5O	0.575
SSB	0.573
WDR59	0.57
TAMM41	0.57
RPE	0.569
LSM11	0.567
OSGEP	0.566
TPRKB	0.564
PPA2	0.563
TBCA	0.563
MED4	0.563
PDAP1	0.563
TSEN34	0.563
RFK	0.561
ATP5B	0.561
UBA3	0.56
PPP6C	0.56
HAUS8	0.559
CBFB	0.558
EXOC3	0.558
UBE2G2	0.557
APAF1	0.556
AASDHPPT	0.555
DHRSX	0.553
CEP57	0.553
TAZ	0.55
DDX55	0.549
ALG6	0.548
PPP2R3C	0.548
POLR3H	0.547
LSM10	0.547
TXNRD1	0.547
RABGGTB	0.546
FAF2	0.546
EEF1E1	0.545
CSNK2B	0.543
TPK1	0.543
DDX39A	0.54
SUPV3L1	0.539
YARS	0.539
TBCB	0.539
CCDC101	0.538
EIF4E	0.537
ELAC2	0.537
C15orf41	0.536
ATP2A2	0.534
TIMM13	0.533
VHL	0.532
CHCHD4	0.532
TELO2	0.532
FNTA	0.531
PPP4C	0.531
DAD1	0.529
GTF2A2	0.528
N6AMT1	0.528
NSD1	0.527
TTI1	0.527
TMEM41B	0.525
GTF3C2	0.525
LAMTOR5	0.524
CCT7	0.521
BCS1L	0.521
ALG14	0.519
EIF3F	0.518
WDR92	0.518
TXNL4B	0.515
UBQLN1	0.514
ENO1	0.514
TMEM242	0.512
CTDNEP1	0.512
AARS	0.512
WDR82	0.51
DDOST	0.51
UXT	0.51
PYROXD1	0.51
EPRS	0.508
SNAPC5	0.508
ALG5	0.507
CTC1	0.505
ATP5A1	0.502
SEC61G	0.502
BUB3	0.502
MBTPS2	0.501
RPN1	0.501
TGS1	0.501
CRCP	0.499
NBN	0.499
SEC62	0.499
ZZZ3	0.499
SRD5A3	0.498
CRLS1	0.498
PAM16	0.497
CMTR1	0.496
DPF2	0.496
MOCS3	0.495
YARS2	0.493
MIS18A	0.492
ATP5D	0.49
KIAA0391	0.487
PPCDC	0.487
VDAC2	0.487
OIP5	0.486
TAF1A	0.484
EIF1AX	0.484
SRP72	0.483
PGM3	0.482
CYCS	0.481
SERF2	0.48
C14orf166	0.48
POLR3B	0.479
C14orf80	0.478
MED23	0.478
DARS2	0.477
PGS1	0.476
CDIPT	0.476
TRIM28	0.473
MSTO1	0.473
ZBTB11	0.472
GTF3A	0.47
SDHA	0.47
TBP	0.47
C17orf89	0.47
MEAF6	0.468
TRMT6	0.468
CHORDC1	0.467
UBE2K	0.467
MRPS14	0.466
WDR1	0.466
C1D	0.464
CTU1	0.463
LSMD1	0.462
RAD50	0.462
SPCS2	0.462
DICER1	0.461
ATP5H	0.461
ERCC2	0.46
SRP68	0.46
RNASEH1	0.46
PGGT1B	0.459
TIMM22	0.459
GEMIN5	0.459
LAMTOR4	0.457
PIK3R4	0.456
SEH1L	0.456
UBE2M	0.456
EFTUD1	0.456
MRPS34	0.456
MAPK14	0.455
MLST8	0.455
SRPRB	0.454
METAP2	0.454
SNF8	0.453
HSD17B10	0.453
NAF1	0.452
NARS	0.452
ZNF608	0.451
MAPKAP1	0.451
NSMCE1	0.451
KDM8	0.45
VMP1	0.45
DCTN6	0.449
MFN1	0.449
PDSS1	0.449
MARCH5	0.448
CEPT1	0.447
ELP6	0.444
POLR3C	0.444
DCTN5	0.444
FEN1	0.443
FGFR1OP	0.443
ZCRB1	0.443
THOC6	0.443
TKT	0.442
SSBP2	0.442
C21orf59	0.441
GPN2	0.44
PDPK1	0.44
RBM14	0.44
SARS2	0.439
TAF11	0.438
CBX3	0.437
RAD1	0.437
UBA5	0.437
CINP	0.437
RBFA	0.437
COX16	0.435
DUSP12	0.434
ZNHIT1	0.434
KCTD5	0.433
NAA20	0.432
GTF2H3	0.432
GATC	0.432
DHDDS	0.432
LMO2	0.432
HARS	0.431
TUBD1	0.431
MLLT1	0.43
VRK1	0.429
TMA16	0.429
UQCR10	0.428
MRPS33	0.428
OBFC1	0.428
PHB	0.427
RBMX2	0.427
PDCD5	0.427
HIST1H4I	0.427
COX5A	0.426
MRPL21	0.426
USO1	0.425
TUFM	0.425
RAD23B	0.423
TUBE1	0.421
ASXL2	0.421
ATP5F1	0.42
MRPS18A	0.42
TMED10	0.42
SLC35B1	0.419
MRPS5	0.419
VPS41	0.419
FNTB	0.418
G6PD	0.418
DAP3	0.417
MRPS16	0.417
PTAR1	0.417
TIMM10	0.417
ID3	0.416
ABCF1	0.416
EXOC5	0.415
XRCC2	0.415
SPR	0.414
CIAO1	0.414
IRF2BP2	0.414
UQCRC2	0.413
BTAF1	0.411
MARS	0.41
SRRD	0.41
DPH3	0.409
ACTR10	0.408
FBXO11	0.406
MRPS6	0.406
ELP4	0.405
OPA1	0.405
RABIF	0.405
ATP5I	0.404
RPUSD4	0.403
ZNF259	0.403
MRPS2	0.402
THOC3	0.401
SGOL1	0.401
TPI1	0.4
ATM	0.4
TOMM22	0.4

Global Fraction of Cell Lines Where Essential: 159/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	3/28
bone	10/26
breast	2/33
central nervous system	15/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	7/21
liver	11/20
lung	19/75
lymphocyte	2/16
ovary	3/26
pancreas	2/24
peripheral nervous system	7/16
plasma cell	2/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	9/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 441
Expression level (log2 read counts): 4.49

Expression Distribution

tRNA guanylyltransferase activity
nucleotidyltransferase activity
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
tRNA binding
tRNA modification
protein homotetramerization
tRNA processing
protein tetramerization
RNA modification
tRNA metabolic process
magnesium ion binding
protein homooligomerization
ncRNA processing
GTP binding
ncRNA metabolic process
protein complex oligomerization
RNA processing
identical protein binding
mitochondrion
ATP binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression