TIA1 [The Human Chemical-Genetic Interaction Map Project]

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======= TIA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIA1
  * **<color #00a2e8>Official Name</color>**: TIA1 cytotoxic granule associated RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7072|7072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31483|P31483]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603518|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear stress granule|
|protein localization to cytoplasmic stress granule|
|poly(A) binding|
|mRNA 3-UTR AU-rich region binding|
|negative regulation of cytokine biosynthetic process|
|positive regulation of epithelial cell apoptotic process|
|cytoplasmic stress granule|
|regulation of epithelial cell apoptotic process|
|fibroblast growth factor receptor signaling pathway|
|regulation of mRNA splicing, via spliceosome|
|regulation of cytokine biosynthetic process|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|negative regulation of translation|
|regulation of RNA splicing|
|regulation of mRNA processing|
|negative regulation of cellular amide metabolic process|
|negative regulation of cytokine production|
|regulation of mRNA metabolic process|
|regulation of translation|
|regulation of cellular amide metabolic process|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cytokine production|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|apoptotic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.78|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.74|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.74|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.77|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.81|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.97|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.17|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15642
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIA1 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>