TIA1

Gene Information

Official Symbol: TIA1
Official Name: TIA1 cytotoxic granule associated RNA binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 7072
UniProt: P31483
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017].
UniProt Summary: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 2μM R00 exp33	-1.78
Cytochalasin-B 5μM R07 exp349	-1.75
JQ1 0.8μM R08 exp435	1.74
NFN1 0.4μM R03 exp99	1.74
Citral 50μM R06 exp274	1.77
Ethanol 0.01 R05 exp234	1.81
LY2090314 0.003μM R08 exp499	1.97
Arsenate 40μM R06 exp264	2.17
GSK626616 14μM R08 exp485	2.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15642
Expression level (log2 read counts): 7.77

Expression Distribution

nuclear stress granule
protein localization to cytoplasmic stress granule
poly(A) binding
mRNA 3-UTR AU-rich region binding
negative regulation of cytokine biosynthetic process
positive regulation of epithelial cell apoptotic process
cytoplasmic stress granule
regulation of epithelial cell apoptotic process
fibroblast growth factor receptor signaling pathway
regulation of mRNA splicing, via spliceosome
regulation of cytokine biosynthetic process
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
negative regulation of translation
regulation of RNA splicing
regulation of mRNA processing
negative regulation of cellular amide metabolic process
negative regulation of cytokine production
regulation of mRNA metabolic process
regulation of translation
regulation of cellular amide metabolic process
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
posttranscriptional regulation of gene expression
response to growth factor
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of cytokine production
positive regulation of cell death
enzyme linked receptor protein signaling pathway
protein localization to organelle
apoptotic process
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process
negative regulation of multicellular organismal process
cellular response to endogenous stimulus
negative regulation of cellular macromolecule biosynthetic process
RNA binding