TICAM2

Gene Information

Official Symbol: TICAM2
Official Name: toll like receptor adaptor molecule 2
Aliases and Previous Symbols: N/A
Entrez ID: 353376
UniProt: Q86XR7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6406
Expression level (log2 read counts): 0.75

Expression Distribution

positive regulation of interleukin-18-mediated signaling pathway
regulation of interleukin-18-mediated signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
TRAM-dependent toll-like receptor signaling pathway
negative regulation of MyD88-independent toll-like receptor signaling pathway
regulation of MyD88-independent toll-like receptor signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
toll-like receptor 4 signaling pathway
regulation of toll-like receptor 4 signaling pathway
necroptotic process
positive regulation of toll-like receptor signaling pathway
phagocytic cup
programmed necrotic cell death
TRIF-dependent toll-like receptor signaling pathway
necrotic cell death
MyD88-independent toll-like receptor signaling pathway
negative regulation of toll-like receptor signaling pathway
COPII-coated ER to Golgi transport vesicle
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
regulation of toll-like receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
endoplasmic reticulum-Golgi intermediate compartment
cell projection
secretory granule membrane
toll-like receptor signaling pathway
late endosome membrane
pattern recognition receptor signaling pathway
Golgi organization
early endosome membrane
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
endosome membrane
endoplasmic reticulum to Golgi vesicle-mediated transport
cellular response to biotic stimulus
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling