TIE1 [The Human Chemical-Genetic Interaction Map Project]

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======= TIE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIE1
  * **<color #00a2e8>Official Name</color>**: tyrosine kinase with immunoglobulin like and EGF like domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7075|7075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35590|P35590]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600222|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000269|PubMed:20227369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane fusion|
|transmembrane receptor protein tyrosine kinase activity|
|vasculogenesis|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|response to retinoic acid|
|negative regulation of vasculature development|
|mesoderm development|
|membrane fusion|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|receptor complex|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to acid chemical|
|in utero embryonic development|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|response to lipid|
|membrane organization|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|negative regulation of developmental process|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|phosphorylation|
|positive regulation of developmental process|
|integral component of plasma membrane|
|ATP binding|
|response to oxygen-containing compound|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.74|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.85|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.93|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9275
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIE1 Expression in NALM6 Cells: 2.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>