TIE1

Official Symbol: TIE1
Official Name: tyrosine kinase with immunoglobulin like and EGF like domains 1
Aliases and Previous Symbols: N/A
Entrez ID: 7075
UniProt: P35590
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000269|PubMed:20227369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

plasma membrane fusion
transmembrane receptor protein tyrosine kinase activity
vasculogenesis
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
response to retinoic acid
negative regulation of vasculature development
mesoderm development
membrane fusion
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
positive regulation of angiogenesis
positive regulation of vasculature development
receptor complex
negative regulation of cell migration
negative regulation of cell motility
regulation of angiogenesis
negative regulation of cellular component movement
angiogenesis
regulation of vasculature development
negative regulation of locomotion
response to acid chemical
in utero embryonic development
blood vessel morphogenesis
blood vessel development
vasculature development
transmembrane receptor protein tyrosine kinase signaling pathway
cardiovascular system development
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
enzyme linked receptor protein signaling pathway
tube development
regulation of cell migration
response to lipid
membrane organization
circulatory system development
peptidyl-amino acid modification
anatomical structure formation involved in morphogenesis
regulation of cell motility