TIFA

Gene Information

Official Symbol: TIFA
Official Name: TRAF interacting protein with forkhead associated domain
Aliases and Previous Symbols: N/A
Entrez ID: 92610
UniProt: Q96CG3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9799
Expression level (log2 read counts): 6.15

Expression Distribution

cytoplasmic pattern recognition receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
pattern recognition receptor signaling pathway
intracellular receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
activation of innate immune response
protein homooligomerization
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
protein complex oligomerization
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
innate immune response
regulation of multi-organism process
positive regulation of immune response
defense response to other organism
positive regulation of intracellular signal transduction
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
regulation of response to stress
protein-containing complex assembly
positive regulation of signal transduction
regulation of immune system process
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling