TIMM23 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM23
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100287932|100287932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14925|O14925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|
|TIM23 mitochondrial import inner membrane translocase complex|
|protein import into mitochondrial matrix|
|protein transmembrane transporter activity|
|protein transmembrane import into intracellular organelle|
|integral component of mitochondrial inner membrane|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|mitochondrial intermembrane space|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|protein import|
|mitochondrial transport|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.76|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.9|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.91|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.92|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.98|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.05|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.33|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.61|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pnpla8|PNPLA8]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 220/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|8/28|
|bone|8/26|
|breast|8/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|4/20|
|lung|30/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|8/24|
|peripheral nervous system|0/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM23 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>