TIMM23

Entrez Summary: The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012].
UniProt Summary: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 0.6μM R03 exp107	1.76
Dynasore 10μM R04 exp180	1.9
Vinblastine 0.002μM R01 exp60	1.91
5-Fluorouracil 20μM R00 exp2	1.92
CoCl2 18μM R07 exp346	1.98
UMK57 1μM R01 exp59	2.05
BI-6727 0.0125μM R03 exp97	2.2
Tubacin 1.6μM R07 exp416	2.33
Rotenone 20μM R00 exp34	2.61
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.83

Global Fraction of Cell Lines Where Essential: 220/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	8/28
bone	8/26
breast	8/33
central nervous system	14/56
cervix	1/4
colorectal	8/17
esophagus	7/13
fibroblast	1/1
gastric	8/16
kidney	6/21
liver	4/20
lung	30/75
lymphocyte	3/16
ovary	4/26
pancreas	8/24
peripheral nervous system	0/16
plasma cell	8/15
prostate	1/1
skin	8/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	8/22
urinary tract	8/29
uterus	2/5

Expression Distribution

P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TIM23 mitochondrial import inner membrane translocase complex
protein import into mitochondrial matrix
protein transmembrane transporter activity
protein transmembrane import into intracellular organelle
integral component of mitochondrial inner membrane
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
mitochondrial intermembrane space
protein localization to mitochondrion
mitochondrial transmembrane transport
protein import
mitochondrial transport
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
intracellular protein transport
mitochondrion
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport