TIMM50

Entrez Summary: This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016].
UniProt Summary: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:15044455}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CB-5083 0.4μM R08 exp468	1.83
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	2.04

interleukin-2 receptor binding
TIM23 mitochondrial import inner membrane translocase complex
protein import into mitochondrial matrix
release of cytochrome c from mitochondria
ribonucleoprotein complex binding
protein transmembrane import into intracellular organelle
phosphoprotein phosphatase activity
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
apoptotic mitochondrial changes
protein serine/threonine phosphatase activity
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
mitochondrial membrane organization
protein import
protein dephosphorylation
mitochondrial transport
apoptotic signaling pathway
dephosphorylation
protein targeting
mitochondrial inner membrane
nuclear speck
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
membrane organization
apoptotic process
intracellular protein transport
programmed cell death
cell death
mitochondrion
transmembrane transport
RNA binding
protein transport
intracellular transport
peptide transport