TKT [The Human Chemical-Genetic Interaction Map Project]

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======= TKT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TKT
  * **<color #00a2e8>Official Name</color>**: transketolase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7086|7086]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29401|P29401]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TKT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TKT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transketolase N|
|Transketolase C|
|Transket pyr|
|E1 dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glyceraldehyde-3-phosphate biosynthetic process|
|xylulose biosynthetic process|
|transketolase activity|
|xylulose metabolic process|
|pentose biosynthetic process|
|pentose-phosphate shunt, non-oxidative branch|
|glyceraldehyde-3-phosphate metabolic process|
|aldehyde biosynthetic process|
|pentose-phosphate shunt|
|NADPH regeneration|
|pentose metabolic process|
|cofactor binding|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|monosaccharide biosynthetic process|
|cellular aldehyde metabolic process|
|peroxisome|
|carbohydrate biosynthetic process|
|vesicle|
|monosaccharide metabolic process|
|nuclear body|
|nuclear speck|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.77|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.75|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.73|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.77|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.83|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.86|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.88|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.89|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.9|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.94|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.01|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.2|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.28|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.75|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.81|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.01|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.23|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.36|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.48|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|3.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpe|RPE]]|0.77|
|[[:human genes:s:srp14|SRP14]]|0.543|
|[[:human genes:e:elp3|ELP3]]|0.525|
|[[:human genes:t:tpi1|TPI1]]|0.523|
|[[:human genes:s:slc25a26|SLC25A26]]|0.523|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.519|
|[[:human genes:d:dnlz|DNLZ]]|0.501|
|[[:human genes:p:pgk1|PGK1]]|0.493|
|[[:human genes:u:urm1|URM1]]|0.486|
|[[:human genes:a:atic|ATIC]]|0.483|
|[[:human genes:t:triap1|TRIAP1]]|0.479|
|[[:human genes:p:pgm3|PGM3]]|0.479|
|[[:human genes:e:eno1|ENO1]]|0.479|
|[[:human genes:r:romo1|ROMO1]]|0.478|
|[[:human genes:t:tamm41|TAMM41]]|0.478|
|[[:human genes:p:pkm|PKM]]|0.477|
|[[:human genes:c:crls1|CRLS1]]|0.471|
|[[:human genes:a:alg1|ALG1]]|0.467|
|[[:human genes:p:pgls|PGLS]]|0.463|
|[[:human genes:d:dpagt1|DPAGT1]]|0.459|
|[[:human genes:p:pgp|PGP]]|0.458|
|[[:human genes:d:dhrsx|DHRSX]]|0.451|
|[[:human genes:c:c14orf80|C14orf80]]|0.451|
|[[:human genes:p:pmm2|PMM2]]|0.449|
|[[:human genes:d:dnajb6|DNAJB6]]|0.446|
|[[:human genes:t:taz|TAZ]]|0.444|
|[[:human genes:t:tubd1|TUBD1]]|0.444|
|[[:human genes:b:bcs1l|BCS1L]]|0.443|
|[[:human genes:t:thg1l|THG1L]]|0.442|
|[[:human genes:r:rpia|RPIA]]|0.442|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.44|
|[[:human genes:l:lsm10|LSM10]]|0.44|
|[[:human genes:d:dohh|DOHH]]|0.434|
|[[:human genes:u:uap1|UAP1]]|0.432|
|[[:human genes:a:atxn10|ATXN10]]|0.431|
|[[:human genes:e:elp2|ELP2]]|0.426|
|[[:human genes:e:elp6|ELP6]]|0.424|
|[[:human genes:g:gpi|GPI]]|0.422|
|[[:human genes:c:cep44|CEP44]]|0.42|
|[[:human genes:r:rtcb|RTCB]]|0.419|
|[[:human genes:g:gemin6|GEMIN6]]|0.416|
|[[:human genes:p:prkrip1|PRKRIP1]]|0.412|
|[[:human genes:c:ctu1|CTU1]]|0.412|
|[[:human genes:t:tsen54|TSEN54]]|0.412|
|[[:human genes:p:ppcs|PPCS]]|0.41|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.41|
|[[:human genes:r:rabggtb|RABGGTB]]|0.409|
|[[:human genes:t:trmt5|TRMT5]]|0.409|
|[[:human genes:g:gemin8|GEMIN8]]|0.408|
|[[:human genes:m:mocs3|MOCS3]]|0.407|
|[[:human genes:a:adsl|ADSL]]|0.404|
|[[:human genes:p:ppcdc|PPCDC]]|0.404|
|[[:human genes:n:nsmce1|NSMCE1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 91/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|0/26|
|breast|11/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|6/21|
|liver|2/20|
|lung|11/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 129
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TKT Expression in NALM6 Cells: 8.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>