TKT

Entrez Summary: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide Riboside 100μM R03 exp139	-1.77
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.75
Apcin 25μM plus proTAME 2μM R04 exp177	-1.73
AICAR 240μM R03 exp116	1.77
BI-D1870 3.15μM R02 exp66	1.83
Centrinone 0.5μM R07 exp343	1.86
Monensin 0.3μM R08 exp507	1.88
UM0125461 0.74μM R02 exp84	1.89
Bortezomib 0.005μM R00 exp6	1.9
Atovaquone 15μM R08 exp451	1.94
MLN-4924 2μM R00 exp22	2
Vinblastine 0.2μM R03 exp108	2.01
MK2206 4μM R08 exp504	2.2
Hippuristanol 0.12μM R08 exp488	2.28
Cytochalasin-B 5μM R07 exp349	2.75
Latrunculin-B 10μM R07 exp374	2.76
Ammonium tetrathiomolybdate 10μM R08 exp448	2.81
Tozasertib 0.1μM R07 exp414	3.01
Arsenate 40μM R06 exp264	3.23
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.36
2-Deoxy-D-glucose 800μM R05 exp214	3.48
Q15 2.7μM R02 exp79	3.56

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	0/26
breast	11/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	4/16
kidney	6/21
liver	2/20
lung	11/75
lymphocyte	0/16
ovary	2/26
pancreas	4/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	8/29
uterus	0/5

Expression Distribution

glyceraldehyde-3-phosphate biosynthetic process
xylulose biosynthetic process
transketolase activity
xylulose metabolic process
pentose biosynthetic process
pentose-phosphate shunt, non-oxidative branch
glyceraldehyde-3-phosphate metabolic process
aldehyde biosynthetic process
pentose-phosphate shunt
NADPH regeneration
pentose metabolic process
cofactor binding
glucose 6-phosphate metabolic process
NADP metabolic process
monosaccharide biosynthetic process
cellular aldehyde metabolic process
peroxisome
carbohydrate biosynthetic process
vesicle
monosaccharide metabolic process
nuclear body
nuclear speck
generation of precursor metabolites and energy
carbohydrate metabolic process
organophosphate biosynthetic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
regulation of growth
protein homodimerization activity
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process
small molecule metabolic process