TLE1

Gene Information

Official Symbol: TLE1
Official Name: TLE family member 1, transcriptional corepressor
Aliases and Previous Symbols: N/A
Entrez ID: 7088
UniProt: Q04724
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269|PubMed:10660609}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12994
Expression level (log2 read counts): 4.58

Expression Distribution

WD40
TLE N

beta-catenin-TCF complex
negative regulation of anoikis
regulation of anoikis
beta-catenin-TCF complex assembly
repressing transcription factor binding
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of canonical Wnt signaling pathway
transcription factor complex
negative regulation of Wnt signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
transcription corepressor activity
regulation of canonical Wnt signaling pathway
transcription factor binding
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
negative regulation of intracellular signal transduction
negative regulation of apoptotic process
negative regulation of programmed cell death
animal organ morphogenesis
negative regulation of cell death
identical protein binding
cell-cell signaling
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
regulation of apoptotic process
negative regulation of biosynthetic process
protein-containing complex assembly
regulation of programmed cell death
negative regulation of response to stimulus