TLE3

Entrez Summary: N/A
UniProt Summary: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Zebularine 20μM R07 exp423	-1.83
VER-155008 3.9μM R06 exp301	-1.82

TLE N
WD40

beta-catenin-TCF complex
beta-catenin-TCF complex assembly
repressing transcription factor binding
negative regulation of cold-induced thermogenesis
regulation of cold-induced thermogenesis
negative regulation of canonical Wnt signaling pathway
transcription factor complex
negative regulation of Wnt signaling pathway
transcription corepressor activity
regulation of canonical Wnt signaling pathway
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
animal organ morphogenesis
cell-cell signaling
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
protein-containing complex assembly
negative regulation of response to stimulus
protein-containing complex subunit organization