TLE4 [The Human Chemical-Genetic Interaction Map Project]

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======= TLE4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLE4
  * **<color #00a2e8>Official Name</color>**: TLE family member 4, transcriptional corepressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7091|7091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04727|Q04727]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLE4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLE4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605132|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|TLE N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-catenin-TCF complex|
|beta-catenin-TCF complex assembly|
|repressing transcription factor binding|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|negative regulation of canonical Wnt signaling pathway|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|transcription corepressor activity|
|regulation of canonical Wnt signaling pathway|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|chromatin binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|molecular function|
|negative regulation of transcription by RNA polymerase II|
|cellular response to cytokine stimulus|
|response to cytokine|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.13|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.06|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.93|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.76|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.72|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.72|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.75|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.77|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.77|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.81|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.87|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.94|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.95|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.03|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.05|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.14|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.14|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.37|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.43|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.44|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.82|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.04|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|4.07|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.657|
|[[:human genes:c:ccdc101|CCDC101]]|0.623|
|[[:human genes:z:znf608|ZNF608]]|0.57|
|[[:human genes:r:rptor|RPTOR]]|0.565|
|[[:human genes:i:id3|ID3]]|0.562|
|[[:human genes:m:mllt1|MLLT1]]|0.554|
|[[:human genes:m:med23|MED23]]|0.542|
|[[:human genes:w:wdr24|WDR24]]|0.534|
|[[:human genes:o:otud5|OTUD5]]|0.53|
|[[:human genes:m:mtor|MTOR]]|0.519|
|[[:human genes:n:nsd1|NSD1]]|0.514|
|[[:human genes:t:taf6l|TAF6L]]|0.51|
|[[:human genes:a:aars|AARS]]|0.509|
|[[:human genes:m:meaf6|MEAF6]]|0.506|
|[[:human genes:t:tada3|TADA3]]|0.495|
|[[:human genes:b:bap1|BAP1]]|0.493|
|[[:human genes:p:pelo|PELO]]|0.488|
|[[:human genes:b:btaf1|BTAF1]]|0.487|
|[[:human genes:v:vhl|VHL]]|0.48|
|[[:human genes:t:tti2|TTI2]]|0.475|
|[[:human genes:u:ube2l3|UBE2L3]]|0.474|
|[[:human genes:c:csnk2b|CSNK2B]]|0.473|
|[[:human genes:u:ubr5|UBR5]]|0.472|
|[[:human genes:c:cbfb|CBFB]]|0.47|
|[[:human genes:e:eny2|ENY2]]|0.469|
|[[:human genes:m:med16|MED16]]|0.469|
|[[:human genes:g:gmppb|GMPPB]]|0.466|
|[[:human genes:m:med25|MED25]]|0.464|
|[[:human genes:c:cbx3|CBX3]]|0.463|
|[[:human genes:t:trim28|TRIM28]]|0.461|
|[[:human genes:g:gnb1l|GNB1L]]|0.459|
|[[:human genes:c:cct7|CCT7]]|0.457|
|[[:human genes:s:supt7l|SUPT7L]]|0.456|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.456|
|[[:human genes:u:ube2g1|UBE2G1]]|0.455|
|[[:human genes:t:trmt5|TRMT5]]|0.455|
|[[:human genes:n:nxt1|NXT1]]|0.453|
|[[:human genes:b:brpf1|BRPF1]]|0.451|
|[[:human genes:m:mapk14|MAPK14]]|0.451|
|[[:human genes:e:eif4e|EIF4E]]|0.448|
|[[:human genes:v:vmp1|VMP1]]|0.446|
|[[:human genes:f:fli1|FLI1]]|0.441|
|[[:human genes:t:tti1|TTI1]]|0.439|
|[[:human genes:r:rnmt|RNMT]]|0.438|
|[[:human genes:h:hspd1|HSPD1]]|0.436|
|[[:human genes:z:znf592|ZNF592]]|0.436|
|[[:human genes:n:nae1|NAE1]]|0.436|
|[[:human genes:s:seh1l|SEH1L]]|0.434|
|[[:human genes:t:thoc6|THOC6]]|0.432|
|[[:human genes:p:pmm2|PMM2]]|0.43|
|[[:human genes:h:hhex|HHEX]]|0.426|
|[[:human genes:t:tada2b|TADA2B]]|0.422|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.421|
|[[:human genes:d:dohh|DOHH]]|0.418|
|[[:human genes:a:alg2|ALG2]]|0.415|
|[[:human genes:u:ube2g2|UBE2G2]]|0.414|
|[[:human genes:t:txnrd1|TXNRD1]]|0.413|
|[[:human genes:n:naa35|NAA35]]|0.411|
|[[:human genes:s:scaf8|SCAF8]]|0.41|
|[[:human genes:x:xpo6|XPO6]]|0.408|
|[[:human genes:t:trip12|TRIP12]]|0.408|
|[[:human genes:s:supt20h|SUPT20H]]|0.408|
|[[:human genes:u:usp22|USP22]]|0.405|
|[[:human genes:d:dnajc3|DNAJC3]]|0.404|
|[[:human genes:t:taf5l|TAF5L]]|0.403|
|[[:human genes:h:helz|HELZ]]|0.403|
|[[:human genes:t:telo2|TELO2]]|0.402|
|[[:human genes:e:erg|ERG]]|0.402|
|[[:human genes:m:max|MAX]]|0.401|
|[[:human genes:p:pax5|PAX5]]|0.401|
|[[:human genes:t:tmem41b|TMEM41B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 63
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLE4 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>