TLE4
Gene Information
- Official Symbol: TLE4
- Official Name: TLE family member 4, transcriptional corepressor
- Aliases and Previous Symbols: N/A
- Entrez ID: 7091
- UniProt: Q04727
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WD40 |
| TLE N |
GO Terms
| beta-catenin-TCF complex |
| beta-catenin-TCF complex assembly |
| repressing transcription factor binding |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| negative regulation of canonical Wnt signaling pathway |
| transcription factor complex |
| negative regulation of Wnt signaling pathway |
| transcription corepressor activity |
| regulation of canonical Wnt signaling pathway |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| chromatin binding |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| molecular function |
| negative regulation of transcription by RNA polymerase II |
| cellular response to cytokine stimulus |
| response to cytokine |
| cell-cell signaling |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of response to stimulus |
| negative regulation of gene expression |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.657 |
| CCDC101 | 0.623 |
| ZNF608 | 0.57 |
| RPTOR | 0.565 |
| ID3 | 0.562 |
| MLLT1 | 0.554 |
| MED23 | 0.542 |
| WDR24 | 0.534 |
| OTUD5 | 0.53 |
| MTOR | 0.519 |
| NSD1 | 0.514 |
| TAF6L | 0.51 |
| AARS | 0.509 |
| MEAF6 | 0.506 |
| TADA3 | 0.495 |
| BAP1 | 0.493 |
| PELO | 0.488 |
| BTAF1 | 0.487 |
| VHL | 0.48 |
| TTI2 | 0.475 |
| UBE2L3 | 0.474 |
| CSNK2B | 0.473 |
| UBR5 | 0.472 |
| CBFB | 0.47 |
| ENY2 | 0.469 |
| MED16 | 0.469 |
| GMPPB | 0.466 |
| MED25 | 0.464 |
| CBX3 | 0.463 |
| TRIM28 | 0.461 |
| GNB1L | 0.459 |
| CCT7 | 0.457 |
| SUPT7L | 0.456 |
| PRKAR1A | 0.456 |
| UBE2G1 | 0.455 |
| TRMT5 | 0.455 |
| NXT1 | 0.453 |
| BRPF1 | 0.451 |
| MAPK14 | 0.451 |
| EIF4E | 0.448 |
| VMP1 | 0.446 |
| FLI1 | 0.441 |
| TTI1 | 0.439 |
| RNMT | 0.438 |
| HSPD1 | 0.436 |
| ZNF592 | 0.436 |
| NAE1 | 0.436 |
| SEH1L | 0.434 |
| THOC6 | 0.432 |
| PMM2 | 0.43 |
| HHEX | 0.426 |
| TADA2B | 0.422 |
| PPP2R3C | 0.421 |
| DOHH | 0.418 |
| ALG2 | 0.415 |
| UBE2G2 | 0.414 |
| TXNRD1 | 0.413 |
| NAA35 | 0.411 |
| SCAF8 | 0.41 |
| XPO6 | 0.408 |
| TRIP12 | 0.408 |
| SUPT20H | 0.408 |
| USP22 | 0.405 |
| DNAJC3 | 0.404 |
| TAF5L | 0.403 |
| HELZ | 0.403 |
| TELO2 | 0.402 |
| ERG | 0.402 |
| MAX | 0.401 |
| PAX5 | 0.401 |
| TMEM41B | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 63
- Expression level (log2 read counts): 7.9
Expression Distribution
TLE4 Expression in NALM6 Cells: 7.9
