TLX2

Gene Information

Official Symbol: TLX2
Official Name: T cell leukemia homeobox 2
Aliases and Previous Symbols: N/A
Entrez ID: 3196
UniProt: O43763
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8387
Expression level (log2 read counts): -4.01

Expression Distribution

enteric nervous system development
negative regulation of dendrite morphogenesis
negative regulation of dendrite development
autonomic nervous system development
mesoderm formation
mesoderm morphogenesis
regulation of dendrite morphogenesis
negative regulation of cell morphogenesis involved in differentiation
formation of primary germ layer
mesoderm development
regulation of dendrite development
negative regulation of neuron projection development
gastrulation
negative regulation of cell projection organization
negative regulation of neuron differentiation
negative regulation of neurogenesis
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
negative regulation of cell development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
cellular component
regulation of cell morphogenesis
regulation of neuron projection development
tissue morphogenesis
embryonic morphogenesis
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
regulation of neurogenesis
anatomical structure formation involved in morphogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
embryo development
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II