TM9SF4

Entrez Summary: N/A
UniProt Summary: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). {ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576, ECO:0000269|PubMed:25999474}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vacuolar proton-transporting V-type ATPase complex assembly
proton-transporting V-type ATPase complex assembly
proton-transporting two-sector ATPase complex assembly
positive regulation of protein exit from endoplasmic reticulum
positive regulation of protein localization to cell surface
regulation of protein exit from endoplasmic reticulum
regulation of protein localization to cell surface
regulation of intracellular pH
regulation of cellular pH
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
positive regulation of intracellular protein transport
positive regulation of intracellular transport
regulation of intracellular protein transport
early endosome
positive regulation of cellular protein localization
phagocytosis
response to hypoxia
regulation of intracellular transport
response to decreased oxygen levels
response to oxygen levels
positive regulation of protein transport
positive regulation of establishment of protein localization
protein localization to membrane
regulation of cellular protein localization
cellular cation homeostasis
cellular ion homeostasis
regulation of protein transport
cation homeostasis
inorganic ion homeostasis
regulation of peptide transport
cellular chemical homeostasis
regulation of establishment of protein localization
ion homeostasis
cellular protein-containing complex assembly
cellular homeostasis
regulation of cellular localization
cell adhesion
biological adhesion