TMBIM4

Entrez Summary: N/A
UniProt Summary: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. {ECO:0000269|PubMed:17319741, ECO:0000269|PubMed:19553469}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	-1.82
39°C R06 exp303	1.71
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.8
QNZ 0.01μM R08 exp439	1.85
Pyrazinamide 100μM R08 exp516	1.9
Trimetrexate 0.03μM R08 exp535	1.92
Vemurafenib 6.6μM R08 exp434	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi stack
regulation of calcium-mediated signaling
Golgi membrane
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
negative regulation of cell death
programmed cell death
cell death
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
regulation of intracellular signal transduction