TMC1 [The Human Chemical-Genetic Interaction Map Project]

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======= TMC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMC1
  * **<color #00a2e8>Official Name</color>**: transmembrane channel like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117531|117531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDI8|Q8TDI8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606706|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TMC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vestibular reflex|
|mechanosensitive ion channel activity|
|detection of mechanical stimulus involved in sensory perception of sound|
|auditory receptor cell development|
|stereocilium tip|
|reflex|
|ion channel activity|
|inner ear auditory receptor cell differentiation|
|detection of mechanical stimulus involved in sensory perception|
|hair cell differentiation|
|voltage-gated calcium channel activity|
|inner ear receptor cell development|
|neuroepithelial cell differentiation|
|detection of mechanical stimulus|
|columnar/cuboidal epithelial cell development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|columnar/cuboidal epithelial cell differentiation|
|detection of external stimulus|
|detection of abiotic stimulus|
|sensory perception of sound|
|regulation of calcium ion transmembrane transport|
|sensory perception of mechanical stimulus|
|epithelial cell development|
|inner ear development|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|ear development|
|regulation of calcium ion transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|epidermal cell differentiation|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|external side of plasma membrane|
|epidermis development|
|regulation of ion transmembrane transport|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|epithelial cell differentiation|
|detection of stimulus|
|regulation of ion transport|
|neuron development|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|neuron differentiation|
|epithelium development|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|cell development|
|tissue development|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.71|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.7|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6070
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMC1 Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>