TMC1

Entrez Summary: This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008].
UniProt Summary: Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vestibular reflex
mechanosensitive ion channel activity
detection of mechanical stimulus involved in sensory perception of sound
auditory receptor cell development
stereocilium tip
reflex
ion channel activity
inner ear auditory receptor cell differentiation
detection of mechanical stimulus involved in sensory perception
hair cell differentiation
voltage-gated calcium channel activity
inner ear receptor cell development
neuroepithelial cell differentiation
detection of mechanical stimulus
columnar/cuboidal epithelial cell development
inner ear receptor cell differentiation
mechanoreceptor differentiation
columnar/cuboidal epithelial cell differentiation
detection of external stimulus
detection of abiotic stimulus
sensory perception of sound
regulation of calcium ion transmembrane transport
sensory perception of mechanical stimulus
epithelial cell development
inner ear development
calcium ion transmembrane transport
response to mechanical stimulus
ear development
regulation of calcium ion transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
epidermal cell differentiation
regulation of cation transmembrane transport
regulation of metal ion transport
external side of plasma membrane
epidermis development
regulation of ion transmembrane transport
detection of stimulus involved in sensory perception
sensory organ development