TMC2 [The Human Chemical-Genetic Interaction Map Project]

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======= TMC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMC2
  * **<color #00a2e8>Official Name</color>**: transmembrane channel like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117532|117532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDI7|Q8TDI7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TMC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vestibular reflex|
|mechanosensitive ion channel activity|
|detection of mechanical stimulus involved in sensory perception of sound|
|stereocilium tip|
|reflex|
|ion channel activity|
|detection of mechanical stimulus involved in sensory perception|
|voltage-gated calcium channel activity|
|detection of mechanical stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|sensory perception of sound|
|regulation of calcium ion transmembrane transport|
|sensory perception of mechanical stimulus|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|regulation of calcium ion transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|cellular component|
|regulation of ion transmembrane transport|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of ion transport|
|molecular function|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-3|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.72|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.26|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.25|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.12|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-2|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.99|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.93|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.87|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.87|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.86|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.86|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.83|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.8|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.8|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.7|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.88|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.446|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10845
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMC2 Expression in NALM6 Cells: 2.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>