TMC2

Entrez Summary: This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Myriocin 25μM R06 exp293	-3
Zebularine 20μM R07 exp423	-2.72
Cisplatin 0.35μM R06 exp273	-2.26
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.25
Genistein 15μM R07 exp360	-2.12
BN82002 4μM R07 exp340	-2
Heregulin-B 44ng/ml R08 exp486	-2
Citral 50μM R06 exp274	-1.99
Mdivi-1 15μM R05 exp217	-1.93
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.87
GW501516 25μM R06 exp285	-1.87
EPZ-5676 30μM R05 exp233	-1.86
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.86
LLY-283 2.6μM R06 exp290	-1.83
Resminostat 0.5μM R07 exp393	-1.8
FBS-Wisent 0.1 R07 exp426	-1.8
A-366 10μM R03 exp115	-1.7
CB-5083 0.4μM R08 exp468	1.83
CFI-400945 25μM R08 exp469	1.88
Golgicide-A 2μM R03 exp121	1.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vestibular reflex
mechanosensitive ion channel activity
detection of mechanical stimulus involved in sensory perception of sound
stereocilium tip
reflex
ion channel activity
detection of mechanical stimulus involved in sensory perception
voltage-gated calcium channel activity
detection of mechanical stimulus
detection of external stimulus
detection of abiotic stimulus
sensory perception of sound
regulation of calcium ion transmembrane transport
sensory perception of mechanical stimulus
calcium ion transmembrane transport
response to mechanical stimulus
regulation of calcium ion transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
regulation of cation transmembrane transport
regulation of metal ion transport
cellular component
regulation of ion transmembrane transport
detection of stimulus involved in sensory perception
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
regulation of ion transport
molecular function
cation transport
ion transmembrane transport
sensory perception
response to abiotic stimulus
transmembrane transport
ion transport
nervous system process