TMEM100 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM100 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM100
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 100
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55273|55273]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NV29|Q9NV29]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM100&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM100|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. {ECO:0000250|UniProtKB:Q9CQG9}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arterial endothelial cell differentiation|
|blood vessel endothelial cell differentiation|
|positive regulation of vasculogenesis|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|regulation of vasculogenesis|
|positive regulation of endothelial cell differentiation|
|endocardial cushion formation|
|cardiac epithelial to mesenchymal transition|
|regulation of endothelial cell differentiation|
|endocardial cushion morphogenesis|
|protein kinase B signaling|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|endocardial cushion development|
|mesenchyme morphogenesis|
|positive regulation of epithelial cell differentiation|
|vasculogenesis|
|epithelial to mesenchymal transition|
|endothelial cell differentiation|
|BMP signaling pathway|
|endothelium development|
|regulation of calcium-mediated signaling|
|cellular response to BMP stimulus|
|response to BMP|
|Notch signaling pathway|
|perikaryon|
|regulation of nervous system process|
|regulation of epithelial cell differentiation|
|mesenchymal cell differentiation|
|positive regulation of vasculature development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|mesenchyme development|
|heart morphogenesis|
|angiogenesis|
|regulation of vasculature development|
|in utero embryonic development|
|blood vessel morphogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|regulation of system process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|enzyme linked receptor protein signaling pathway|
|molecular function|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|endoplasmic reticulum|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.89|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5890
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM100 Expression in NALM6 Cells: -2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>